2024年7月20日 · Cerebral cavernous malformations (CCMs) are groups of tightly packed, irregular small blood vessels with thin walls. They may be present in the brain or spinal cord. …

2024年7月3日 · Conclusions: CCM3 is critical for maintaining blood-brain barrier integrity and CCM3 loss-induced mTORC1 signaling in brain EPCs initiates and facilitates CCM …

2021年1月25日 · Cerebral cavernous malformations (CCMs) are vascular abnormalities that primarily occur in adulthood and cause cerebral hemorrhage, stroke, and seizures. CCMs are …

2018年9月11日 · Cerebral cavernous malformations (CCMs) are neurovascular lesions caused by mutations in one of three genes (CCM1–3). Loss of CCM3 causes the poorest prognosis, and …

CCM3 maintains cell junction by inhibiting ERK1/2 phosphorylation; CCM3 inhibits stress fibre migration and endothelial permeability by inhibiting RhoA signalling; CCM3 regulates …

CCM occurs in both sporadic and familial forms; familial cases follow an autosomal-dominant mode of inheritance and are caused by mutations in CCM1 (KRIT1), CCM2 (MGC4607), or …

2020年12月30日 · The programmed cell death 10 (PDCD10) gene was originally identified as an apoptosis-related gene, although it is now usually known as CCM3, as the third causative …

2019年3月2日 · The current review focuses on the signalling pathways mediated by CCM3 in regulating endothelial cell junction, proliferation, migration and permeability. These findings …

脑静脉畸形3，也称为脑静脉畸形3，与脑静脉畸形2和海绵状血管瘤有关。 与脑静脉畸形3有关的重要基因是PDCD10（程序性细胞死亡10）。 附属组织包括大脑和骨髓，相关表型为头痛和 …

CCM3 is an extremely rare and serious mutation that causes cavernous malformations in the brain and spinal cord. A mutation of the CCM3 gene can result in a multi-systemic syndrome …