CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes [6] through binding to the receptors CCR1, CCR4 and CCR5.

Dec 24, 2024 · CCL3 (C-C Motif Chemokine Ligand 3) is a Protein Coding gene. Diseases associated with CCL3 include Human Immunodeficiency Virus Type 1 and Aseptic Meningitis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.

Macrophage inflammatory protein-1 alpha (MIP-1α/CCL3) is a chemotactic chemokine secreted by macrophages. It performs various biological functions, such as recruiting inflammatory cells, wound healing, inhibition of stem cells, and maintaining ...

May 19, 2006 · Antibodies specific for CC-chemokine ligand 3 (CCL3) or CCL4 inhibited the accumulation of OT-I T cells in lymph nodes containing activated OT-II T cells. Both CD4 + T cells and DCs were...

CCL3, also known as macrophage inflammatory protein 1α (MIP-1α), induces inflammatory cytokines to specific sites by binding to the CCR1/3/9 receptors (Li et al., 2020). CCL3 is mainly produced by mononuclear macrophages, lymphocytes, and neutrophils, but can also be produced by …

CCL3 or macrophage inflammatory protein-1α (MIP-1α), an important chemokine implicated in both immune surveillance and tolerance, has emerged as a prognostic biomarker in both solid and hematological malignancies.

Feb 3, 2011 · In response to BCR activation, CLL cells secrete the chemokine CCL3, which fosters interactions between CLL cells and the leukemia microenvironment. CCL3 secretion correlates with expression of the 70-kDa ζ-associated protein (ZAP-70) and responsiveness of the CLL clone to BCR stimulation.