C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene. [5] This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines.

2024年12月24日 · CCL27 (C-C Motif Chemokine Ligand 27) is a Protein Coding gene. Diseases associated with CCL27 include Melanoma and Molluscum Contagiosum. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include chemokine activity.

趋化因子配体27 (ccl27)，也被称为皮肤t细胞吸引趋化因子(ctack)，是cc趋化因子家族中的小分子量细胞因子。 这种因子的基因位于人类的第9号染色体上。 CCL27在许多组织中表达，包括生殖腺、胸腺、胎盘和皮肤。

ccl27，也称皮肤 t 细胞吸引趋化因子(ctack)，是一种 cc 趋化因子，在人类基因组中位于第 9 号染色体上。 CCL27 在基底角质形成细胞中表达丰富。 在正常皮肤的基底上层角质形成细胞中表达最低；然而在人类 AD、接触性皮炎和牛皮癣的病变中，它们表现出更强的 ...

2022年5月18日 · Here, we report that the chemokine CCL27 is critical for establishment of resident lymphocytes and immune homeostasis in barrier tissues. CCL27 expression is associated with normal skin and hair follicle development independent of commensal bacterial stimulation, indicative of a homeostatic role for the chemokine.

2025年2月8日 · CCL27 drives baseline recruitment of Herpes simplex virus-specific CD8 T cells expressing CCR10, while interferon-responsive CXCR3 ligands recruit additional cells in response to virus-driven inflammation.

In this chapter, we address the role of chemokine CCL27 in the tumor microenvironment in the most relevant cancers of the skin and other anatomical locations. We also make a brief comment on future perspectives and the potential relation of CCL27 with different immunotherapeutic modalities. CXCL-10: a new candidate for melanoma therapy?

2010年8月25日 · The chemokine CCL27 has chemoattractant properties for memory T cells and has been implicated in skin allergic reactions. The present study reports the expression in the brain of two CCL27 splice variants localized in the cerebral cortex and limbic regions. CCL27-like immunoreactivity was identified mainly in neurons.

Moreover, several studies have shown an association between CCL27 expression and a variety of neoplasms including skin cancer.In this chapter, we address the role of chemokine CCL27 in the tumor microenvironment in the most relevant cancers of the skin and other anatomical locations.

Our findings demon-strate that CCL27 is critical for immune homeostasis across barrier tissues. Barrier tissues, including the skin and mucosa, harbor a diverse complement of immune cells. These tissue-resident immune cells protect against …