Core binding factor acute myeloid leukaemia is a cancer related to genetic changes in the CBF gene. It is most commonly caused by an inversion of particular region of chromosome 16; however it can also be caused by translocation between copies of chromosome 16. The rearrangements cause formation of CBF but with impaired function.

Mar 12, 2025 · College Football 25 News, Tools, and Community - CFB.FAN

Jan 2, 2020 · Here, we identify nonsilent mutations, which may collaborate with CBF-rearrangements during leukemogenesis by targeted sequencing of 129 genes in 292 adult CBF leukemia patients, and thus provide a comprehensive overview of the mutational spectrum (‘mutatome’) in CBF leukemia.

The CBFB gene provides instructions for making a protein called core binding factor beta (CBFβ), which is one piece of a protein complex known as core binding factor (CBF). CBFβ attaches (binds) to one of three related RUNX proteins (RUNX1, RUNX2, or RUNX3) to form different versions of CBF.

Dec 24, 2024 · CBFB (Core-Binding Factor Subunit Beta) is a Protein Coding gene. Diseases associated with CBFB include Cleidocranial Dysplasia 2 and Acute Myeloid Leukemia With Abnormal Bone Marrow Eosinophils Inv (16) (P13q22) Or T (16;16) (P13;Q22).

Jun 16, 2021 · Core binding factor acute myelogenous leukemia (CBF-AML), characterized by the presence of either t (8;21) (q22;q22) or inv (16) (p13q22)/t (16;16), is considered good-risk AML in the...

May 6, 2019 · Translation and transcription are frequently dysregulated in cancer. These two processes are generally regulated by distinct sets of factors. The CBFB gene, which encodes a transcription factor, has recently emerged as a highly mutated driver in a variety of human cancers including breast cancer.

Feb 9, 2025 · Study found that CBFB binds to and enhances the translation of RUNX1 mRNA, which encodes the binding partner of CBFB. CBFB binds and regulates the translation of hundreds of mRNAs through hnRNPK and facilitate translation initiation by eIF4B.

May 6, 2019 · RNA immunoprecipitation followed by deep sequencing (RIP-seq) reveals that cytoplasmic CBFB binds to hundreds of transcripts and regulates their translation. CBFB binds to mRNAs via hnRNPK and...

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