Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. [5][6]

2024年12月24日 · CBFB (Core-Binding Factor Subunit Beta) is a Protein Coding gene. Diseases associated with CBFB include Cleidocranial Dysplasia 2 and Acute Myeloid Leukemia With Abnormal Bone Marrow Eosinophils Inv (16) (P13q22) Or T (16;16) (P13;Q22).

2025年2月9日 · Study found that CBFB binds to and enhances the translation of RUNX1 mRNA, which encodes the binding partner of CBFB. CBFB binds and regulates the translation of hundreds of mRNAs through hnRNPK and facilitate translation initiation by eIF4B.

The CBFB gene provides instructions for making a protein called core binding factor beta (CBFβ), which is one piece of a protein complex known as core binding factor (CBF). CBFβ attaches (binds) to one of three related RUNX proteins (RUNX1, RUNX2, or RUNX3) to form different versions of CBF.

2020年1月2日 · Here, we identify nonsilent mutations, which may collaborate with CBF-rearrangements during leukemogenesis by targeted sequencing of 129 genes in 292 adult CBF leukemia patients, and thus provide a...

由该基因编码的蛋白质是属于 PEBP2/CBF 转录因子家族的异二聚体核心结合转录因子的 β 亚基，该转录因子主要调节一系列造血功能 (例如 RUNX1) 和成骨 (例如 RUNX2) 特异性基因. beta 亚基是一个非 DNA 结合的调节亚基；它通过变构增强 α 亚基的 DNA 结合，因为复合物结合到各种增强子和启动子的核心位点，包括鼠白血病病毒、多瘤病毒增强子、T 细胞受体增强子和 GM-CSF 启动子。 可变剪接产生两个 mRNA 变体，每个变体编码一个不同的羧基末端。 在某些情况 …

2019年5月6日 · Here we report a noncanonical role of CBFB in translation regulation. RNA immunoprecipitation followed by deep sequencing (RIP-seq) reveals that cytoplasmic CBFB binds to hundreds of...

2025年1月5日 · CBF-beta isoform 1 and isoform 2 stabilize HIV-1 Vif to degrade A3G and increase viral infectivity. CBF-beta stabilizes Vif proteins from multiple HIV-1 subtypes (A, B, …

2021年5月4日 · Here, we analyze genetic interactions between mutations of CBFB and other highly mutated genes in human breast cancer datasets and find that CBFB and TP53 mutations are mutually exclusive, suggesting a functional association between CBFB and p53. Integrated genomic studies reveal that TAp73 is a common transcriptional target of CBFB and p53.

2022年10月24日 · Core-binding factor (CBF) binds to the core site of murine leukemia virus and also to the enhancers of the T-cell receptor genes, and the core site appears to be a major genetic determinant of the tissue specificity of leukemias induced by the murine leukemia virus.