The cartilage matrix consists of macromolecules in which collagen and proteoglycans (aggrecan) are the main representatives. These components are highly ordered from the cartilage surface to the deepest layers.

2022年10月17日 · The cartilage matrix consists of fibrous tissue and various combinations of proteoglycans and glycosaminoglycans. Cartilage, once synthesized, lacks lymphatic or blood supply, and the movement of waste and nutrition is chiefly done …

The cartilage matrix comprises a network of collagen fibrils enmeshed in a concentrated PG solution. The collagen and PGs interact to form a porous composite fiber-reinforced organic solid matrix that is swollen with water (Mow and Hung, 2001).

Cartilage is a flexible connective tissue that differs from bone in several ways. For one, the primary cell types are chondrocytes as opposed to osteocytes. Chondrocytes are first chondroblast cells that produce the collagen extracellular matrix (ECM) and …

2017年8月31日 · Formed by the process of chondrogenesis, the resulting chondrocytes are capable of producing large amounts of collagenous extracellular matrix and ground substance, which together form cartilage itself. This article explains the structure, composition, formation and histology of cartilage.

Articular cartilage (AC) sheathes joint surfaces and minimizes friction in diarthrosis. The resident cell population, chondrocytes, are surrounded by an extracellular matrix and a multitude of proteins, which bestow their unique characteristics.

In this review, we focus on the important role of volume control-related ion channels in cartilage matrix remodeling and summarize current views. In addition, the potential mechanism of the volume-sensitive anion channel LRRC8A in the early occurrence of osteoarthritis is discussed.

Articular cartilage is adapted to be able to perceive and respond to mechanical load. Indeed, physiological loads are essential to maintain cartilage thickness in a healthy joint and excessive mechanical stress is associated with the breakdown of the matrix that is …

Cartilage ECM is composed mainly of two components defining its mechano-physical properties: the collagenous network, responsible for the tensile strength of the cartilage matrix, and the proteoglycans (mainly aggrecan), responsible for the osmotic swelling and the elastic properties of the cartilage tissue.

Know the major components of cartilage matrix and understand how they are responsible for cartilage resilience. Understand the two types of cartilage formation in adults (appositional and interstitial growth) and the role of mesenchymal stem cells in the perichondrium.