CAMK, also written as CaMK or CCaMK, is an abbreviation for the Ca2+/calmodulin-dependent protein kinase class of enzymes. CAMKs are activated by increases in the concentration of intracellular calcium ions (Ca 2+) and calmodulin.

Ca 2+ /calmodulin-dependent protein kinase (CaMK) is a Ser/Thr kinase activated by binding of a versatile Ca 2+ -signal transducer, calmodulin (CaM), to various extracellular stimuli, including hormones, neurotransmitters, etc., resulting in an increasing intracellular Ca 2+ …

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene. [5] The product of this gene belongs to the serine/threonine protein kinase cluster, and to the Ca 2+ /calmodulin-dependent protein kinase (CAMK) group.

There are two types of CaM kinases: Specialized CaM kinases, such as the myosin light chain kinase that phosphorylates myosin, causing smooth muscles to contract. Multifunctional CaM kinases, also collectively called CaM kinase II, which play a role in neurotransmitter secretion, transcription factor regulation, and glycogen metabolism.

Ca 2+ /calmodulin stimulated protein kinase kinase (CaMKK) is a multifunctional protein kinase encoded by two genes (CAMKK1 and CAMKK2) that produce CaMKKα or CaMKKβ [3], respectively. The CAMKK2 gene produces several splicing isoforms depending on cell type [4, 5].

Calcium (Ca 2+) is an essential ligand that binds its primary intracellular receptor Calmodulin (CaM) to trigger a variety of downstream processes and pathways.

2022年9月2日 · Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant protein in excitatory synapses and is central to synaptic plasticity, learning and...

2020年7月13日 · Calcium/calmodulin-dependent protein kinases (CaMKs) are key regulators of calcium signaling in health and disease. CaMKII is the most abundant isoform in the heart; although classically described as a regulator of excitation–contraction coupling, recent studies show that it can also mediate inflammation in cardiovascular diseases (CVDs).

2020年11月2日 · Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) is a serine/threonine-protein kinase belonging to the Ca 2+ /calmodulin-dependent protein kinase subfamily. CAMKK2 has an autocatalytic site, which gets exposed when Ca 2+ /calmodulin (CAM) binds to it. This results in autophosphorylation and complete activation of CAMKK2.

2022年9月20日 · We summarize the current knowledge of the structural, functional, and physiological properties of the regulatory kinase, CaMKK, and the development and application of its pharmacological inhibitors. Keywords: Ca2+ signaling; CaM-kinase cascade; CaMKK; phosphorylation.