Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein; it is a receptor for calcitonin gene-related peptide. [5] The protein encoded by the CALCRL gene is a G protein-coupled receptor related to the calcitonin receptor.

2024年12月24日 · CALCRL (Calcitonin Receptor Like Receptor) is a Protein Coding gene. Diseases associated with CALCRL include Lymphatic Malformation 8 and Hydrops Fetalis, Nonimmune. Among its related pathways are Response of endothelial cells to shear stress and GPCR downstream signalling.

2021年11月1日 · Calcitonin receptor‐like (CALCRL) is a G-protein coupled neuropeptide receptor involved in various biological processes such as proliferation, apoptosis, and inflammation. 4,5 It can be activated by 2 ligands, adrenomedullin (ADM) and calcitonin gene-related peptide.

2025年2月8日 · Overall, our study demonstrates that CALCRL predicts outcome beyond existing risk factors and is a potential therapeutic target in AML. hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia.

Little information is available concerning protein expression of the calcitonin receptor-like receptor (CALCRL) at the protein level. Here, we developed a rabbit monoclonal antibody, 8H9L8, which is directed against human CALCRL but cross-reacts with the rat and mouse forms of the receptor.

Calcitonin receptor-like (CALCRL) is a G-protein-coupled neuropeptide receptor involved in the regulation of blood pressure, angiogenesis, cell proliferation, and apoptosis, and is currently emerging as a novel target for the treatment of migraine.

2021年1月18日 · CALCRL knockdown impairs leukemic growth, decreases LSC frequency, and sensitizes to cytarabine in patient-derived xenograft models. Mechanistically, the ADM-CALCRL axis drives cell cycle,...

2024年2月1日 · The results showed that overexpression of CALCRL in HL-60 and Molm-13 could confer resistance properties to AML cells and reduce the DNA damage and cell cycle G0/G1 phase blocking effects caused by daunorubicin (DNR) and others. Overexpression of CALCRL also reduced DNR-induced apoptosis.

2025年1月4日 · Title: The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia. hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia.

2024年4月11日 · CALCRL (calcitonin receptor-like) protein is an important mediator of the endothelial fluid shear stress response, which is associated with the genetic risk of coronary artery disease.