
CACNA1G Gene - GeneCards | CAC1G Protein | CAC1G Antibody
2024年12月24日 · CACNA1G (Calcium Voltage-Gated Channel Subunit Alpha1 G) is a Protein Coding gene. Diseases associated with CACNA1G include Spinocerebellar Ataxia 42 and Spinocerebellar Ataxia 42, Early-Onset, Severe, With Neurodevelopmental Deficits .
CACNA1G - Wikipedia
Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Ca v 3.1 is a protein which in humans is encoded by the CACNA1G gene. [5] [6] [7] It is one of the primary targets in the pharmacology of absence seizure.
A Review of the CACNA Gene Family: Its Role in Neurological …
The CACNA1G gene encodes the calcium voltage-gated channel subunit alpha1 G, also known as subunit Cav3.1, primarily found in the postsynaptic regions of the cerebellum, hippocampus, thalamus, and heart.
CALCIUM CHANNEL, VOLTAGE-DEPENDENT, T TYPE, ALPHA-1G SUBUNIT; CACNA1G
2018年8月13日 · The CACNA1G gene encodes the low-voltage-activated Ca(v)3.1 T-type calcium channel. CACNA1G is highly expressed in Purkinje neurons and deep cerebellar nuclei (summary by Chemin et al., 2018). Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing ...
CACNA1G calcium voltage-gated channel subunit alpha1 G
The results of this study provide support for Cacna1g as a genetic modifier in a mouse model of Dravet syndrome and suggest that Cav3.1 may be a potential molecular target for therapeutic intervention in patients; CACNA1G variant is associated with differential antiepileptic drug response in childhood absence epilepsy.
A Review of the CACNA Gene Family: Its Role in Neurological
2024年5月5日 · This review delves into the significance of the CACNA genes, including CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1G, and CACNA1H, in the pathogenesis of conditions such as migraine, epilepsy, …
钙电压门控通道亚基 alpha1 G(CACNA1G)基因 | MCE
电压敏感钙通道介导钙离子进入可兴奋细胞,并且还参与多种钙依赖性过程,包括肌肉收缩、激素或神经递质释放、基因表达、细胞运动、细胞分裂和细胞死亡。 该基因编码一个 T 型、低电压激活的钙通道。 由于快速失活,T 型通道产生的电流既是瞬态电流,又是由于小电导而产生的微小电流。 T 型通道被认为与起搏器活动、低阈值钙尖峰、神经元振荡和共振以及反弹爆发放电有关。 许多编码不同亚型的选择性剪接转录物变体已被描述用于该基因。 [RefSeq 提供,2011 年 9 月]
CACNA1G calcium voltage-gated channel subunit alpha1 G
2025年1月5日 · Long non-coding RNA CACNA1G-AS1 promotes cell migration, invasion and epithelial-mesenchymal transition by HNRNPA2B1 in non-small cell lung cancer. A T-type channel-calmodulin complex triggers αCaMKII activation.
CACNA1G人源基因|CACNA1G基因突变_致病性_靶点-RDDC官网
A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia. Molecular cloning and functional expression of Ca (v)3.1c, a T-type calcium channel from human brain.
A mutation in the low voltage-gated calcium channel CACNA1G ... - PubMed
2015年12月29日 · Results: In this study, we analyzed a Japanese family with autosomal dominant SCA using linkage analysis and exome sequencing, and identified CACNA1G, which encodes the calcium channel CaV3.1, as a new causative gene. The same mutation was also found in another family with SCA.