Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. This class of enzymes is divided up into a number of subcategories, including CYP1, CYP2, and CYP3, which as a group are largely responsible for the breakdown ...

cyp2e1是肝内 三氯乙烯 、 氟烷 、安氟醚、七氟醚代谢的重要酶。 约5%的七氟醚可很快代谢为 氟化物 和hexafluoro isopropanol (HFIP)，再被 糖醛酸 化后经尿排泄。

Dec 24, 2024 · CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1) is a Protein Coding gene. Diseases associated with CYP2E1 include Alcoholic Liver Cirrhosis and Alcohol Use Disorder . Among its related pathways are Isoflurane Pathway, Pharmacokinetics and Oxidation by cytochrome P450 .

Besides the detoxifying role of CYP2E1 for compounds such as electrophilic agents, reactive oxygen species, free radical products, and the bioactivation of xenobiotics, CYP2E1 is also related in several diseases and pathophysiological conditions. In this review, we describe the presence of phase I monooxygenase CYP2E1 in regions of the brain.

This study presents a timely systematic review on CYP2E1's xenobiotic metabolism, genetic polymorphism, and inhibitors, with the focus on their clinical relevance for the efficacy and toxicity of various CYP2E1 substrates.

P450 2E1 is also involved in the bioactivation of a number of low molecular weight cancer suspects, as validated in vivo in mouse models where cancers could be attenuated by deletion of Cyp2e1. P450 2E1 does not have a role in global production of reactive oxygen species but localized roles are possible, e.g. in mitochondria.

细胞色素p450 2e1(cyp2e1)是机体对药物和低分子化合物代谢的主要酶之一,且cyp2e1的活性增强或高表达与临床多种疾病密切相关.文章综述了国内外cyp2e1的蛋白结构,功能,定位机制及基因多态性等方面的研究进展.从而为进一步探索机体内cyp2e1的生物学效应及其与临床 ...

CYP2E1 is expressed abundantly within the microsomes of certain brain cells and is localized to particular brain regions. This chapter focuses on the discussion of CYP2E1 in ethanol metabolism in the CNS, covering topics including how it is regulated, where it is expressed and how it influences sensitivity to ethanol in the brain. 8.1 Introduction

cyp2e1还是有效的活性氧生成物，例如超氧阴离子自由基和过氧化氢，在铁催化剂存在下，cyp2e1会产生强力氧化剂，例如羟基自由基。 这篇综述文章总结了CYP2E1的一些生化和毒理学特性，并简要介绍了开发用于组成型表达人CYP2E1的HepG2细胞系在评估CYP2E1的作用中的 ...

This review describes some of the biochemical and toxicological properties of CYP2E1, especially as it relates to alcohol metabolism and toxicity and the establishment of human hepatoma HepG2 cell lines that overexpress human CYP2E1. Ethanol, polyunsaturated fatty acids, and iron were found to be cytotoxic in HepG2 cells that overexpress CYP2E1.