Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. This class of enzymes is divided up into a number of subcategories, including CYP1, CYP2, and CYP3, which as a group are largely responsible for the breakdown ...

Besides the detoxifying role of CYP2E1 for compounds such as electrophilic agents, reactive oxygen species, free radical products, and the bioactivation of xenobiotics, CYP2E1 is also related in several diseases and pathophysiological conditions.

CYP2E1 is expressed abundantly within the microsomes of certain brain cells and is localized to particular brain regions. This chapter focuses on the discussion of CYP2E1 in ethanol metabolism in the CNS, covering topics including how it is regulated, where it is expressed and how it influences sensitivity to ethanol in the brain. 8.1 Introduction

2024年12月24日 · CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1) is a Protein Coding gene. Diseases associated with CYP2E1 include Alcoholic Liver Cirrhosis and Alcohol Use Disorder . Among its related pathways are Isoflurane Pathway, Pharmacokinetics and Oxidation by cytochrome P450 .

Cytochrome P450 2E1 (CYP2E1) plays a vital role in drug-induced hepatotoxicity and cancers (e.g. lung and bladder cancer), since it is responsible for metabolizing a number of medications and environmental toxins to reactive intermediate metabolites.

2020年5月1日 · That role is shared with two other enzymes that oxidize ethanol, alcohol dehydrogenase and catalase. P450 2E1 is also involved in the bioactivation of a number of low molecular weight cancer suspects, as validated in vivo in mouse models where cancers could be attenuated by deletion of Cyp2e1.

CYP2E1 has the highest catalytic activity among the members of cytochrome P450 enzymes in metabolizing alcohol (ethanol). The role of CYP2E1 becomes particularly important when CYP2E1 is upregulated following chronic and acute alcohol exposure in hepatocytes and in wild-type (WT) animals [1, 44, 48].

The cDNA of human CYP2E1 can be successfully cloned, and a cell line, HepG2-CYP2E1 can efficiently express mRNA and has CYP2E1 activity. This study shown that the genotypes of CYP2E1 are associated with clinical features of alcoholics.

CYP2E1 is located within the placental trophoblast, and has been detected in this tissue during all three trimesters (Hakkola et al. 1996). CYP2E1 is most notably involved in the bioactivation of procarcinogens and metabolism of low-molecular-weight compounds.

2025年2月8日 · Title: Cytochrome P450 2E1 (CYP2E1) positively regulates lipid catabolism and induces browning in 3T3-L1 white adipocytes. DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and …