Chemokine receptor CXCR3 is a Gα i protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. There are three isoforms of CXCR3 in humans: CXCR3-A, CXCR3-B and chemokine receptor 3-alternative (CXCR3-alt). [5]

趋化因子受体cxcr3是g蛋白偶连的七跨膜域受体，可选择性地与cxc趋化因子（cxcl9，cxcl10，和cxcl11）结合 [1] 。 cxcr3又称g蛋白偶联受体9(gpr9)和cd183。 CXCR3又称G蛋白偶联受体9(GPR9)和CD183。

2024年12月24日 · CXCR3 (C-X-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CXCR3 include Cutaneous Lupus Erythematosus and Pulmonary Sarcoidosis . Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling .

2011年3月10日 · CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells following activation and preferentially remains highly expressed on Th1-type CD4(+) T cells and effector CD8(+) T cells.

cxcr3及其配体 cxcl9 、 cxcl10 和 cxcl11 与许多肿瘤的发展和进展密切相关。随着其作用机制的阐明，cxcr3有望成为评估肿瘤患者预后的新指标和临床肿瘤免疫治疗的新靶点。 cxcr3及其配体的组成和作用. 趋化因子受体cxcr3由三种 ifn-γ 诱导配体cxcl9、cxcl10和cxcl11激活诱导。

The CXC subgroup of chemokine receptors, CXCR3, is mainly expressed on the surface of activated T cells, B cells, and natural killer cells, and plays an essential role in infection, autoimmune diseases, and tumor immunity by binding to specific receptors on target cell membranes to induce targeted migration and immune responses.

CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells following activation and preferentially remains highly expressed on ...

2023年7月11日 · Genetic ablation of CXCR3 in Treg cells disrupted DC1-Treg cell interactions and concomitantly increased DC-CD8 + T cell interactions. Mechanistically, CXCR3 ablation in Treg cells increased tumor antigen-specific cross-presentation by DC1s, increasing CD8 + T cell priming and reactivation in tumors.

2022年1月18日 · CXCR3 is a chemokine receptor expressed by populations of antigen-experienced CD8+ T cells, including T MEM and T INT cells, and has been implicated in driving T cells into the splenic red pulp and toward an effector fate in settings of early acute infection and vaccination (Hu et al., 2011; Kohlmeier et al., 2011; Kurachi et al., 2011; Shah et ...

2023年6月30日 · The chemokine receptor CXCR3 responds to the chemokines CXCL9, CXCL10, and CXCL11, which are induced by interferons (IFNs) and are critical for immune cell control of cancer. 30, 31 However, unlike CCR4 and CCR8 that are increased on Treg cells, compared with effector T cells in tumors, CXCR3 is expressed on many effector cells in tumors ...