The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the …

2024年12月24日 · CRX (Cone-Rod Homeobox) is a Protein Coding gene. Diseases associated with CRX include Cone-Rod Dystrophy 2 and Leber Congenital Amaurosis 7. Among its …

The CRX gene provides instructions for making a protein called the cone-rod homeobox protein. Learn about this gene and related health conditions.

To describe phenotypic, genotypic, and histopathological features of inherited retinal dystrophies associated with the CRX gene (CRX-RDs).

CRX gene mutations are responsible for about one-quarter of the cases of a form of the condition called autosomal dominant cone-rod dystrophy. These mutations lead to a reduction in the …

2022年7月1日 · Cone-rod homeobox (CRX; OMIM∗602225) is a transcription factor highly expressed in rod and cone photoreceptors, which is essential for their development and …

1997年11月14日 · We have isolated and characterized a novel member of the otx homeodomain gene family, Crx. Crx is expressed exclusively in photoreceptor cells in the neural retina. In the …

One of the isolated cDNAs encoded a novel gene, which the authors termed CRX for 'cone-rod homeobox-containing gene.' CRX encodes a 299-amino acid protein with a predicted mass of …

Title: Allele-specific gene editing to rescue dominant CRX-associated LCA7 phenotypes in a retinal organoid model. Downregulation of CRX, a Group 3-specific oncogenic transcription …

This study aims to review the pathogenic mechanisms of various CRX mutations and propose two therapeutic strategies to rescue sick photoreceptors in CRX-associated retinopathies, namely, …