Breast: presence of CK19+ peripheral blood tumor cells or CK19+ fragments is a poor prognostic factor for breast cancer (predicts CNS relapse, Breast Cancer Res 2006;8:R36) Liver: distinguish hepatocellular carcinoma (CK19-) from either hepatoid adenocarcinoma metastatic to liver (CK19+, Am J Surg Pathol 2003;27:1302 ) or cholangiocarcinoma ...

Keratin-19 is a type I keratin. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells.

2020年6月28日 · Cytokeratin 19 (CK19) is well acknowledged as a biliary/progenitor cell marker and a marker of tumor stem cell. CK19-positive HCCs demonstrate aggressive behaviors and poor outcomes which including worse overall survival and early tumor recurrence after hepatectomy and liver transplantation.

2025年1月10日 · A 0% expression level of CK19 protein may be an optimal threshold for predicting the prognosis of CK19-positive HCC. Based on this, CK19 marker a good nomogram model was constructed to predict HCC prognosis.

Monoclonal antibodies against trophectoderm-specific markers during mouse blastocyst formation. Proceedings of the National Academy of Sciences of the United States of America 77.7 (1980 Jul): 4113-7.

CK19 increases its expression level during epithelial embryogenesis, tissues regeneration, tissue repair as well as tissue development and has shown to have an increasing expression in carcinogenesis of CK19-positive cancers from normal tissues to premalignant lesions to carcinoma in situ.

2024年12月25日 · KRT19 (Keratin 19) is a Protein Coding gene. Diseases associated with KRT19 include Breast Cancer and Eccrine Porocarcinoma. Among its related pathways are Developmental Cell Lineages and Keratinization. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton.

2022年11月25日 · Cytokeratin19 is the acid keratin with the lowest molecular weight belonging to the family of intermediate filaments. Cytokeratin 19 is a simple acid keratin of 40 KDa molecular weight, encoded by the KRT19 gene, located on the chromosome 17, in position 17q21.2.

Cytokeratin 19 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains. Due to manufacturing & supply chain issues, this product is …

2022年9月9日 · Anti-cytokeratin 19 reacts with simple and complex epithelia, including the glandular and ductal epithelium of organs such as the gastrointestinal tract and breast and squamous epithelium.