The Chromodomain-Helicase DNA-binding 1 is a protein that, in humans, is encoded by the CHD1 gene. [5] [6] [7] CHD1 is a chromatin remodeling protein that is widely conserved across many eukaryotic organisms, from yeast to humans.

Dec 24, 2024 · CHD1 (Chromodomain Helicase DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with CHD1 include Pilarowski-Bjornsson Syndrome and Stroke, Ischemic. Among its related pathways are ESR-mediated signaling and Signal Transduction.

Oct 11, 2017 · Chd1 is required for the passage of RNA polymerase IIthrough nucleosomes 6 and for cellular pluripotency 7. Chd1 contains the DNA-binding domains SANT and SLIDE, a bilobal motor domain that...

CHD1 is the 5q21 tumor suppressor gene in prostate cancer; findings suggest that CHD1 deletion may underlie cell invasiveness in a subset of prostate cancers, and indicate a possible novel role of altered chromatin remodeling in prostate tumorigenesis

CHD1 is a conserved chromatin remodeling enzyme required for development and linked to prostate cancer in adults, yet its role in human cells is poorly understood. Here, we show that targeted disruption of the CHD1 gene in human cells leads to a ...

Aug 11, 2021 · Chd1 is an ATP-dependent chromatin remodeler that binds specifically to H3K4me3 and is found at sites of active transcription 8, 9. Chd1 removes nucleosomal barriers to transcriptional...

Sep 20, 2017 · The CHD1 gene encodes a ubiquitously expressed ATP-dependent chromatin remodeling protein that regulates the opening of chromatin and plays a role in transcription (summary by Pilarowski et al., 2018).