Cyclin-dependent kinase inhibitor 1B (p27 Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. [5] It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins.

2024年12月24日 · CDKN1B (Cyclin Dependent Kinase Inhibitor 1B) is a Protein Coding gene. Diseases associated with CDKN1B include Multiple Endocrine Neoplasia, Type Iv and Primary Hyperparathyroidism. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Defective binding of RB1 mutants to E2F1, (E2F2, E2F3).

The CDKN1B gene provides instructions for making a protein called p27. This protein is found in cells and tissues throughout the body. Within cells, p27 is located primarily in the nucleus, where it plays a critical role in controlling cell growth and division.

Cyclin-dependent kinase inhibitor 1B (CDKN1B) was identified as a direct target of negative regulation by miR-222-3p in NP cells, and expression of miR-222-3p was found to be negatively correlated with that of CDKN1B in intervertebral disc degeneration tissue.

Chromosome 12: 12,867,992-12,875,305 forward strand. This gene has 4 transcripts (splice variants), 2 paralogues and is associated with 64 phenotypes. Sorry, the page request "/Homo_sapiens/Component/Gene/Summary/gene_summary?db=core;g=ENSG00000111276;r=12:12867992-12875305;time=1740417039702.702" failed to load.

2025年2月9日 · Title: MicroRNA-221-3p promotes post-burn HUVEC proliferation, migration, and angiogenesis by regulating CDKN1B. Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression.

The CDKN1B gene encodes for the p27Kip1 protein, firstly characterized as a cyclin dependent kinase (CDK)-inhibitor. Germline CDKN1B pathogenic variants have been described in hereditary tumors, such as multiple endocrine neoplasia (MEN)-like ...

Somatic CDKN1B gene mutations have been identified in sporadic (nonfamilial) pituitary adenomas and in sporadic parathyroid adenomas, which are noncancerous tumors of the parathyroid glands.

Cyclin-dependent kinase inhibitor 1B (CDKN1B, also known as p27) is a gene that encodes a protein that binds to and inhibits the activation of cyclin E/CDK2 or cyclin D/CDK4 complexes in order to regulate cell cycle progression at G1.

1998年5月1日 · - CDKN1B is a negative regulator implicated in G1 arrest mediated by TGFb, cell-cell contact, agents that elevate cyclic AMP and rapamycin; CDKN1B binds to and acts as a stoichiometric inhibitor of G1-cyclin-cyclin dependent kinase complexes (cyclin E-Cdk2, cyclin A-Cdk2, cyclin D-Cdk4 (restriction point), controlling G1 to S phase transition ...