The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK8 and cyclin C associate with the mediator complex and regulate transcription by several mechanisms. CDK8 binds to and/or phosphorylates several transcription factors, which can have an activating or inhibitory effect on transcription factor function. [7] [8] CDK8 phosphorylates the Notch ...

Dec 24, 2024 · CDK8 (Cyclin Dependent Kinase 8) is a Protein Coding gene. Diseases associated with CDK8 include Intellectual Developmental Disorder With Hypotonia And Behavioral Abnormalities and Ebstein Anomaly.Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Epigenetic regulation by WDR5-containing histone modifying complexes.

Jan 14, 2019 · CDK8 and its paralog, CDK19, collectively termed 'Mediator Kinase,' are cyclin-dependent kinases that have been implicated as key rheostats in cellular homeostasis and developmental programming. CDK8 and CDK19 are incorporated, in a mutually exclusive manner, as part of a 4-protein complex called the Mediator kinase module.

Jan 24, 2010 · CDK8 is a kinase found in some Mediator complexes and has been implicated in oncogenesis. Now it is shown to be a positive regulator of transcription elongation at immediate early serum response ...

CDK8 regulates the transcription factors turnover, C-terminal domain phosphorylation, and regulates the activator or repressor functions. (Review) Cdk8 is required for stress-induced Mdv1-Dnm1 interaction and mitochondrial fragmentation. Here, loss of CDK8 suppressed the reduced mRNA expression and RNAPII occupancy levels of CTD truncation mutants.

Notably, CDK8 has been shown to phosphorylate several transcription factors in yeast, and this phosphorylation triggers nuclear export and transcription factor degradation by the proteasome (Chi et al. 2001; Nelson et al. 2003). Thus, CDK8 kinase activity may initiate disassembly and degradation of the PIC.

Aug 11, 2023 · CDK8/19 inhibition under basal conditions initially downregulated a small group of genes, most of which were inducible by serum or PKC stimulation. Prolonged CDK8/19 inhibition or mutagenesis upregulated a larger gene set, along with a post-transcriptional increase in the proteins comprising the core Mediator complex and its kinase module. ...

The CDK8 kinase exists in a 600 kDa complex known as the CDK8 module, which consists of four proteins (CDK8, CCNC, MED12, MED13). The CDK8 module associates with regulatory sites on a genome-wide scale [ 1 – 3 ], and global targeting of the CDK8 module appears to reflect its association with the 26-subunit Mediator complex[ 4 ].

Sep 14, 2008 · CDK8, a general transcriptional regulator, functions in part by enhancing the activity of the Wnt signalling pathway. Morris et al. report that E2F1, a transcription factor that is a target of pRB ...

Mar 12, 2025 · The CDK8-AHL10-SUVH2/9 module is critical for transcriptional dynamics in response to salt stress. Salt stress has devastating effects on agriculture, yet the key regulators modulating the ...