Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene. [5] [6] The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases.

2022年5月20日 · Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against CDK2 are ATP...

2024年12月24日 · CDK2 (Cyclin Dependent Kinase 2) is a Protein Coding gene. Diseases associated with CDK2 include Breast Cancer and Endometrial Hyperplasia. Among its related pathways are Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects and CDK-mediated phosphorylation and removal of Cdc6.

In dividing cells, cyclin-dependent kinase 2 (CDK2) is a major cell cycle component that controls the G1/S and S/G2 transitions.

CDK2 and its regulatory subunits are deregulated in many human cancers and there is emerging evidence suggesting CDK2 inhibition elicits antitumor activity in a subset of tumors with defined genetic features. Previous CDK2 inhibitors were nonspecific and limited by off-target effects.

Cyclin dependent kinase 2 (CDK2) is responsible for enforcing progression through the G1-S phase transition. Mutations and alterations in the CDK2 signaling pathway are associated with various cancers, most commonly breast, ovarian, prostate, leukemia, and lymphoma.

2019年5月9日 · Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S- and M-phases of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is critically associated with tumor growth in multiple cancer types.

Cyclin-dependent kinase 2 (CDK2) is a protein kinase that is essential for controlling cell division and the cell cycle. CDK2 dysregulation has been linked to several cancer forms, leading to it being an ideal target for therapeutic development.

2020年4月17日 · Cyclin-dependent kinase 2 (CDK2) controls cell division and is central to oncogenic signaling. We used an “in situ” approach to identify CDK2 substrates within nuclei isolated from cells expressing CDK2 engineered to use adenosine 5′-triphosphate analogs.

2025年2月9日 · Here, the authors investigate CDK2-dependancy and response to CDK2 inhibition across different cancers, identifying markers of sensitivity and combinatorial therapeutic strategies.