2024年12月24日 · CDH13 (Cadherin 13) is a Protein Coding gene. Diseases associated with CDH13 include Vater/Vacterl Association and Atherosclerosis. Among its related pathways are Cell junction organization and ERK Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and cadherin binding.

T-cadherin, also known as cadherin 13, H-cadherin (heart), and CDH13, is a unique member of the cadherin protein family. Unlike typical cadherins that span across the cell membrane with distinct transmembrane and cytoplasmic domains, T-cadherin lacks these features and is instead anchored to the cell's plasma membrane through a GPI anchor.

2015年10月13日 · Cadherin-13 (CDH13), a unique glycosylphosphatidylinositol-anchored member of the cadherin family of cell adhesion molecules, has been identified as a risk gene for...

CDH13 regulates axonal outgrowth and synapse formation, substantiating its relevance for neurodevelopmental processes. Several studies support the influence of CDH13 on personality traits, behavior, and executive functions. However, evidence for functional effects of common gene variation in the CDH13 gene in humans is sparse.

2021年5月10日 · Cadherin-13 (CDH13) has been associated with autism and attention-deficit/hyperactivity disorder. CDH13 localizes at inhibitory presynapses, specifically of parvalbumin (PV) and...

摘 要:T- 钙黏蛋白(T-Cadherin/H-Cadherin, CDH13) 是非典型的钙黏素家族中的一员。 研究发现,CDH13广泛分布于正常细胞表面,而在肺癌、乳腺癌、宫颈癌等多种恶性肿瘤中表达下调,并证实与肿瘤的不良预后有关。 在肿瘤中CDH13 的再表达可抑制肿瘤细胞的增殖与侵袭。 这些特性表明,CDH13可能成为恶性肿瘤风险评估和监测预后的新的分子生物学标志。 现就近年来CDH13在恶性肿瘤中的研究进展进行综述。 关键词:T-钙黏蛋白;甲基化;表观遗传学;肿瘤中图分类号:Q785 …

该基因编码钙粘蛋白超家族的一个成员。 编码的蛋白质位于细胞膜表面，并由 GPI 部分锚定，而不是跨膜结构域。 该蛋白缺乏其他钙粘蛋白的细胞质结构域特征，因此不被认为是细胞间粘附糖蛋白。 这种蛋白质在神经分化过程中充当轴突生长的负调节剂。 它还保护血管内皮细胞免受氧化应激引起的细胞凋亡，并与抗动脉粥样硬化有关。 该基因在许多类型的癌症中都被高度甲基化。 可变剪接导致编码不同异构体的多个转录变体。 [RefSeq 提供，2011 年 5 月] This gene …

2025年1月4日 · CDH13 is associated with working memory performance in attention deficit/hyperactivity disorder. Arias-Vásquez A, et al. Genes Brain Behav, 2011 Nov. PMID 21815997. What's a GeneRIF? Hsa_circ_0000119 promoted ovarian cancer development via enhancing the methylation of CDH13 by sponging miR-142-5p.

Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks. A Common CDH13 Variant Is Associated with Low Agreeableness and Neural Responses to Working Memory Tasks in ADHD.

2025年2月8日 · CDH13 is a negative regulator of inhibitory synapses in the hippocampus, and provide insights into how CDH13 dysfunction may contribute to the excitatory/inhibitory imbalance observed in Attention Deficit Disorder with Hyperactivity.