2024年12月24日 · CDC42 (Cell Division Cycle 42) is a Protein Coding gene. Diseases associated with CDC42 include Takenouchi-Kosaki Syndrome and Nocarh Syndrome. Among its related …

Cdc42 impairs the insulin secretion and promotes IR via suppressing the activity of PAK-1. Cdc42 can affect IR in adipose tissue by (a) interaction of CIP4 with TC10; (b) Gαq/11 participating in …

Cdc42 localizes to membranes via a post-translational C-terminal geranylgeranyl lipid modification; however, it can be found as a soluble complex association with RhoGDI (Rho …

2025年2月9日 · Cdc42 is a critical regulator of T cell actin dynamics, T cell receptor clustering, and cell cycle entry. Cdc42 activity in specific locations at specific times is most critical for its …

Recent studies by conditional gene targeting of cdc42 in mice have revealed its tissue- and cell type-specific role and provide definitive information of the physiological signaling functions of …

2019年1月6日 · Cdc42, a member of the Rho GTPases family, is involved in the regulation of several cellular functions including cell cycle progression, survival, transcription, actin …

A hallmark of endothelial senescence is the persistent up-regulation of pro-inflammatory genes. We identified CDC42 signaling as a mediator of chronic inflammation associated with …

Consistent with the involvement of Cdc42 in EMT-mediated cell movement, overexpression of the Cdc42 GEF, ARHGEF9, is commonly observed in hepatocellular carcinoma samples and …

2020年6月11日 · Cdc42 is a major regulator of ROS formation, degranulation as well as activation of neutrophils in a stimulus dependent manner. We reported that Cdc42 seems to be a …

Cdc42 is particularly known for its unique role in controlling cell polarity and in modulating polarized cell functions, including the proper formation of epithelial tight and adherens …