CD69 (Cluster of Differentiation 69) is a human transmembrane C-Type lectin protein encoded by the CD69 gene. It is an early activation marker that is expressed in hematopoietic stem cells, T cells, and many other cell types in the immune system. [ 5 ]

CD69 is a membrane-bound, type II C-lectin receptor. It is a classical early marker of lymphocyte activation due to its rapid appearance on the surface of the plasma membrane after stimulation.

Dec 24, 2024 · CD69 (CD69 Molecule) is a Protein Coding gene. Diseases associated with CD69 include Coccidioidomycosis and Eosinophilic Pneumonia. Among its related pathways are Extrafollicular and follicular B cell activation by SARS-CoV-2 and Hematopoietic Stem Cells and Lineage-specific Markers.

CD69 is a recognized classical marker of white blood cell activation. 1 It appears faster on the cytoplasmic membranes of activated cells than CD25 2 and is thus regarded as an early marker of lymphocyte activation. CD69 can be expressed in hematopoietic or immune cells and plays a …

CD69 is an early leukocyte activation marker involved in the regulation of the immune response. Initial in vitro studies evaluated its function using monoclonal antibodies until knock-out mice were developed. Subsequently, four ligands for CD69 have ...

CD69 is a type II C-lectin membrane receptor with a scarce expression in resting lymphocytes that is rapidly induced upon cell activation.

CD69 is an early leukocyte activation molecule expressed at sites of chronic inflammation. The precise role of CD69 in immunity has not been elucidated owing to the absence of a known ligand and adequate in vivo models to study its physiological function.

4 days ago · The CD69 + CD103− phenotype exhibited characteristics of exhaustion, whereas CD69 + CD103 + displayed a resident phenotype. Although both subsets possess antitumor responses, the latter demonstrated stronger antitumor activity, and was identified as the primary effector cell in suppressing in situ tumor recurrence.

Cluster of differentiation 69 (CD69), known as an early leukocyte activation marker, can be used as a measure or early marker of T cell activation. In recent years, the functions of CD69 in the regulation of Treg/Th17 (T helper cell 17) differentiation and in the tissue retention of T cells have attracted considerable interest.

Aug 4, 2024 · CD69, a type II transmembrane protein, is encoded by the CD69 gene located on chromosome 12. Structurally, it belongs to the C-type lectin superfamily, characterized by a carbohydrate-recognition domain.