CD59 glycoprotein, also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene. [5] It is an LU domain and belongs to the LY6 / uPAR / alpha-neurotoxin protein family .

CD59，亦稱為「膜攻擊複合物（MAC）抑制蛋白」（MAC-inhibitory protein, MAC-IP）、「膜反应性溶血抑制物」（membrane inhibitor of reactive lysis, MIRL）、「膜攻擊複合物抑制因子」（membrane attack complex inhibitory factor, MACIF）或保護素（protectin） [6] ，在人體內是一種由CD59基因編 ...

2024年12月24日 · CD59 (CD59 Molecule (CD59 Blood Group)) is a Protein Coding gene. Diseases associated with CD59 include Hemolytic Anemia, Cd59-Mediated, With Or Without Immune-Mediated Polyneuropathy and Primary Cd59 Deficiency. Among its related pathways are Transport to the Golgi and subsequent modification and Complement cascade.

2025年2月1日 · CD59，亦称为“膜攻击复合物（MAC）抑制蛋白”（MAC-inhibitory protein, MAC-IP）、“膜反应性溶血抑制物”（membrane inhibitor of reactive lysis, MIRL）、“膜攻击复合物抑制因子”（membrane attack complex inhibitory factor, MACIF）或保护素（protectin） [6] ，在人体内是一种由CD59基因 ...

2024年4月25日 · cd59是一种膜攻击复合物抑制因子，cd59缺乏可引起阵发性睡眠性血红蛋白尿症（pnh），cd59低表达与糖尿病、多发性硬化等自身免疫性疾病相关，cd59也是多种恶性肿瘤的生物标志物，cd59是一个很有潜力的疾病诊断和治疗靶标。

2023年6月1日 · CD59 regulates immune system and protects cells from complement system. CD59 deficiency is associated with paroxysmal nocturnal hemoglobinuria (PNH). CD59 is implicated in cancer, autoimmune disorders, and diabetes mellitus. CD59 has potential as a …

2023年2月16日 · CD59 is an abundant immuno-regulatory receptor that protects human cells from damage during complement activation. Here we show how the receptor binds complement proteins C8 and C9 at the...

In this review, we describe the structure and biological activities of CD59, the pathogenic role of MAC formation, and discuss application of soluble molecules of CD59 for therapeutic use. CD59 regulates complement activation cascade at the final step, inhibiting formation of membrane attack complex (MAC).

CD59, also known membrane inhibitor of reactive lysis (MIRL), or protectin, is encoded by the CD59 gene. It is attached to cells via a Glycosylphosphatidylinositol (GPI) anchor. CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex.

CD59 has been identified as a glycosylphosphatidylinositol-anchored membrane protein that acts as an inhibitor of the formation of the membrane attack complex to regulate complement activation. Recent studies have shown that CD59 is highly expressed in several cancer cell lines and tumor tissues.