2024年12月24日 · CD55 (CD55 Molecule (Cromer Blood Group)) is a Protein Coding gene. Diseases associated with CD55 include Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy and Blood Group, Cromer System .

Decay-accelerating factor (DAF or CD55) is a known inhibitor of the complement system and has recently attracted substantial attention due to its role in various diseases, such as cancer, protein-losing enteropathy, and malaria.

2017年7月6日 · We identified homozygous loss-of-function mutations in the gene encoding CD55 (decay-accelerating factor), which lead to loss of protein expression. Patients’ T lymphocytes showed increased...

2024年4月24日 · CD55, or decay accelerating factor, is a membrane lipid microdomain-associated, GPI-anchored protein implicated in the shielding of cells from complement-mediated attack via accelerating decay of C3 and C5. Loss of CD55 is associated with a number ...

2024年3月1日 · CD55 is a membrane-bound complement regulator that interferes with complement activation, an important component of innate immunity. CD55 also regulates adaptive immunity-CD55 downregulation is critical for germinal center reactions.

CD55, also known as decay-accelerating factor (DAF), is a membrane protein that plays a crucial role in regulating the complement system by preventing the formation of the C3 convertase enzyme complex.

2022年10月21日 · CD55/CD59-neutralizing antibody treatment or mutation of the LINC00973 promoter activates the complement and CD8 + T cells, inhibiting tumor growth. Importantly, combined anti-CD55/CD59 and...

2022年12月28日 · CD55, or decay accelerating factor, is a membrane lipid microdomain-associated, GPI-anchored protein implicated in the shielding of cells from complement-mediated attack via accelerating decay of C3 and C5.

2018年2月20日 · Decay-accelerating factor (DAF or CD55) is a known inhibitor of the complement system and has recently attracted substantial attention due to its role in various diseases, such as cancer, protein-losing enteropathy, and malaria.

CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE) disease is caused by abnormal complement activation due to biallelic loss-of-function mutations in CD55.