The importance of CD45RB expression on T cells was already shown in mice where CD45RB(high) expression determines pathogenic potential. In this study, we analyzed the expression of CD45RA, CD45RB, and CD45RO on CD4(+) T lymphocytes in the intestinal mucosa and in the circulation of patients with inf …

2024年3月1日 · cd45的抗体包括名称分别为cd45、cd45ra、cd45rb、cd45ro、cd45r的不同抗体。 Mouse CD45蛋白有两个等位的基因，CD45.1和CD45.2，其中CD45.1的小鼠品系包括FVB、RIII、SJL/J、STS/A、DA等，表达CD45.2的小鼠品系包括AKR、BALB/c、CBA/Ca、CBA/J、C3H/He、C57BL、C57BR、C57L、C58、DBA/1、DBA/2、NZB ...

2020年2月4日 · Krummey et al. show that viral CD8+ T cell memory has heterogeneous CD45 isoform expression. Low-affinity CD8+ T cells have high CD45RB expression and a CD27hiCD62Lhi phenotype relative to high-affinity CD45RBlo CD8+ T cells, which possess an effector-like phenotype. CD45RBhi cells survive better under homeostatic conditions in vivo.

We investigate two subsets of CD45RA-CD45RO+ CD4+ human T cells which differ by fourfold in their expression of the CD45RB isoform; one is CD45RBbright and the other is CD45RBintermediate. In contrast, CD45RA+ naive cells are all CD45RBbright.

2024年8月9日 · Our results thus identify that stably expressed CD45RB levels can be exploited to trace resting memory B cells and their activated progeny, and suggest that atypical and non-classical CD45RBlo ...

CD45RB is a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.

CD45RBhi and CD45RBlo memory cells that underwent homeo-static proliferation in a sub-lethally irradiated host largely main-tain pre-transfer CD45RB expression levels (82% for CD45RBhi and 76% for CD45RBlo)(Figure S1C). To better characterize extracellular CD45 domain expression on LCMV memory, we assessed the expression of CD45RA,

CD45RB contains only one of the three alternatively spliced exons (exon 5). CD45RB is an isoform of CD45 with exon 5 splicing (encodes B determinant). It is a 220 kD glycoprotein expressed on peripheral B cells, naïve T cells, thymocytes, weakly on …

数据显示 CD45 的交联，特别是 CD45RB 同种型，增强小胶质细胞对 Abeta(1-42) 肽的吞噬作用，并抑制 LPS 诱导的 p44/42 和 p38 通路激活。 小胶质细胞与激动剂 CD45 抗体的共同处理导致 LPS 诱导的小胶质细胞 TNF-α 和 IL-6 通过 p44/42 和/或 p38 途径释放的显着抑制。

2001年5月1日 · CD45 (also known as B220, CD45R, CD45RA, CD45RB, CD45RC, CD45RO, EC 3.1.3.48, LCA, T200, Ly5 and PTPRC) was cloned as a major leukocyte cell surface molecule of high molecular weight 1.