
Expression of CD45RB functionally distinguishes intestinal T ...
The importance of CD45RB expression on T cells was already shown in mice where CD45RB(high) expression determines pathogenic potential. In this study, we analyzed the expression of CD45RA, CD45RB, and CD45RO on CD4(+) T lymphocytes in the intestinal mucosa and in the circulation of patients with inf …
CD45靶点解析:不只是个marker-南京福麦斯生物技术有限公司
2024年3月1日 · cd45的抗体包括名称分别为cd45、cd45ra、cd45rb、cd45ro、cd45r的不同抗体。 Mouse CD45蛋白有两个等位的基因,CD45.1和CD45.2,其中CD45.1的小鼠品系包括FVB、RIII、SJL/J、STS/A、DA等,表达CD45.2的小鼠品系包括AKR、BALB/c、CBA/Ca、CBA/J、C3H/He、C57BL、C57BR、C57L、C58、DBA/1、DBA/2、NZB ...
CD45RB Status of CD8 + T Cell Memory Defines T Cell ... - Cell Press
2020年2月4日 · Krummey et al. show that viral CD8+ T cell memory has heterogeneous CD45 isoform expression. Low-affinity CD8+ T cells have high CD45RB expression and a CD27hiCD62Lhi phenotype relative to high-affinity CD45RBlo CD8+ T cells, which possess an effector-like phenotype. CD45RBhi cells survive better under homeostatic conditions in vivo.
CD45RB expression defines two interconvertible subsets of
We investigate two subsets of CD45RA-CD45RO+ CD4+ human T cells which differ by fourfold in their expression of the CD45RB isoform; one is CD45RBbright and the other is CD45RBintermediate. In contrast, CD45RA+ naive cells are all CD45RBbright.
Atypical and non-classical CD45RB - Nature
2024年8月9日 · Our results thus identify that stably expressed CD45RB levels can be exploited to trace resting memory B cells and their activated progeny, and suggest that atypical and non-classical CD45RBlo ...
CD45RB Monoclonal Antibody (C363.16A), PE (12-0455-82)
CD45RB is a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
CD45RBhi and CD45RBlo memory cells that underwent homeo-static proliferation in a sub-lethally irradiated host largely main-tain pre-transfer CD45RB expression levels (82% for CD45RBhi and 76% for CD45RBlo)(Figure S1C). To better characterize extracellular CD45 domain expression on LCMV memory, we assessed the expression of CD45RA,
CD45 characterization & Isoforms - Mini-review - Bio-Rad
CD45RB contains only one of the three alternatively spliced exons (exon 5). CD45RB is an isoform of CD45 with exon 5 splicing (encodes B determinant). It is a 220 kD glycoprotein expressed on peripheral B cells, naïve T cells, thymocytes, weakly on …
CD45RB 是一种新型分子治疗靶点,可抑制 Abeta 肽诱导的小胶质 …
数据显示 CD45 的交联,特别是 CD45RB 同种型,增强小胶质细胞对 Abeta(1-42) 肽的吞噬作用,并抑制 LPS 诱导的 p44/42 和 p38 通路激活。 小胶质细胞与激动剂 CD45 抗体的共同处理导致 LPS 诱导的小胶质细胞 TNF-α 和 IL-6 通过 p44/42 和/或 p38 途径释放的显着抑制。
CD45: new jobs for an old acquaintance - Nature Immunology
2001年5月1日 · CD45 (also known as B220, CD45R, CD45RA, CD45RB, CD45RC, CD45RO, EC 3.1.3.48, LCA, T200, Ly5 and PTPRC) was cloned as a major leukocyte cell surface molecule of high molecular weight 1.
- 某些结果已被删除