Through this CD200/CD200R signaling pathway, CD200 exerts its immunosuppressive effects by inhibiting natural killer (NK) cell activation, cytotoxic T cell functions, and M1-polarized macrophage activity, while also facilitating expansion of myeloid-derived suppressor cells (MDSCs) and Tregs.

We show that CD200 is uniformly expressed in chronic lymphocytic leukemia (CLL) and absent in mantle cell lymphoma (MCL). Importantly, expression of CD200 is retained even in those CLLs with immunophenotypic aberrancies, making CD200 a particularly useful marker for discrimination between these cases and MCL.

Dec 24, 2024 · CD200 (CD200 Molecule) is a Protein Coding gene. Diseases associated with CD200 include Hairy Cell Leukemia and Indian Tick Typhus. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is NECTIN1.

CD200 is a transmembrane protein related to the B7 family of costimulatory receptors involved in T-cell signaling and likely plays a role in physiologic immune tolerance. It is normally expressed on lymphoid and neuronal tissue, and its receptor, CD200R, is expressed on antigen-presenting cells and T-cells.

May 12, 2021 · Our data show that the CD200-CD200R pathway restrains activation of CD200R+ lesional macrophages, their production of CCR2 ligands, and monocyte recruitment in vitro and in vivo in an air pouch model.

CD200 and its receptor, CD200R, constitutes an endogenous inhibitory signaling, and is being increasingly recognized in studies of various central nervous system (CNS) disorders. Emerging data have demonstrated that neuronal CD200 binds to CD200R to modulate immune responses to pathogenic stimuli.

Feb 23, 2024 · CD200 + DKK3 + fibroblasts stabilized the type 2 innate lymphoid cell phenotype and induced resolution of arthritis via CD200–CD200R1 signaling. Taken together, these data suggest a dynamic...

Feb 5, 2024 · Compared to their CD200R low counterparts, sepsis-generated CD200R high neutrophils exhibit impaired autophagy and dysfunction, with reduced chemotactic migration, superoxide anion production,...

Jan 18, 2023 · Here, we found an increase in tumor-infiltrating CD200 + cytotoxic T lymphocytes (CTLs) upon PD-1/PD-L1 blockade, with higher proportions of CD200 + T cells positively related to a favorable clinical outcome to anti–PD-1/PD-L1 therapy in three independent cohorts of patients with cancer.

Nov 25, 2020 · CD200, a transmembrane type Ia glycoprotein belonging to the immunoglobulin protein superfamily, is broadly expressed on a wide variety of cell types, such as B lymphocytes, a subset of T lymphocytes, dendritic cells, endothelial and neuronal cells.