CD20 is a transmembrane protein consisting of four hydrophobic transmembrane domains, one intracellular domain and two extracellular loops. There are three different forms of CD20 according to variable phosphorylation. CD20 is located on the cell surface as homo-dimeric and homo-tetrameric oligomers.

2022年4月19日 · Though they all bind CD20, there are differences among these antibodies. Some are referred to as chimeric such as rituximab, which means the bio-engineers used a 'mix of construction materials' to craft the antibody, some human, some mouse; some are humanized (obinutuzumab) and some are fully human (ofatumumab), meaning all parts come from human gene => protein sources.

Anti-CD20 monoclonal antibodies act through several mechanisms, including complement-dependent cytotoxicity (CDC), complement-dependent cellular cytotoxicity (CDCC), antibody-dependent cellular phagocytosis (ADCP), antibody-dependent cellular cytotoxicity (ADCC), and induction of direct apoptosis.

Mechanisms of action of therapeutic CD20 mAbs. CD20 mAbs can induce tumor killing in several ways. A. Direct binding of CD20 mAbs initiate the crosslinking of multiple CD20 molecules, resulting in cell-death via induction of non-classical apoptosis; B. Activation of complement result in complement-dependent cytotoxicity; C. recognition of opsonized tumor cells by FcγRs expressed on immune ...

CD20 (cluster of differentiation 20) is a protein that is expressed on the surface of B cells, starting at the pre-B cell stage and on mature B cells in the bone marrow and in the periphery. CD20 is not expressed on hematopoietic stem cells, pro-B cells, or normal plasma cells.(1) Plasmablasts and stimulated plasma cells may express CD20.(2 ...

CD20. CD20, a B cell marker, is a nonglycosylated 33–37 kDa phosphoprotein member of the MS4A family, which forms a tetraspan membrane-bound protein. The extracellular portion of CD20 is 44 amino acids in length and provides the docking site for anti-CD20 MAbs binding (Teeling et al., 2006; Ruuls et al., 2008).CD20 expression is initiated at the pre-B cell stage of development and remains ...

2021年9月20日 · Rituximab is a chimeric murine / human anti-CD20 antibody used to treat B cell lymphomas; treatment may cause selection of CD20 negative (but CD79a positive) tumor subclones (Am J Surg Pathol 2005;29:1399, Ann Hematol 2020;99:2141) Changes in morphology and CD20 expression after rituximab therapy vary widely (Am J Surg Pathol 2013;37:563, Ann Hematol 2020;99:2141)

CD20 is a B cell-specific membrane protein and represents an attractive target for therapeutic antibodies. Despite widespread usage of anti-CD20 antibodies for B cell depletion therapies, the biological function of their target remains unclear.

4 天之前 · Structural differences in antigen binding influence CD20 clustering on the B-cell surface, affecting apoptotic efficiency. Types Of Anti-CD20 Monoclonal Antibodies. Anti-CD20 monoclonal antibodies are classified based on their structural composition and origin, which influence immunogenicity, efficacy, and mechanism of action.

CD20 is a protein primarily expressed on the surface of B cells, a type of white blood cell that plays a key role in the immune system’s defense against infections.This protein is expressed throughout the entire B cell development process, from pre-B cells to mature B cells, but is not present on plasma cells, which are the cells that make antibodies.