
CD160 - Wikipedia
CD160 is a 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity.
CD160 Gene - GeneCards | BY55 Protein | BY55 Antibody
2024年12月24日 · CD160 (CD160 Molecule) is a Protein Coding gene. Diseases associated with CD160 include Folliculitis and Kummell's Disease. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
CD160 expression on CD8 + T cells is associated with active ... - PubMed
CD160 is an Ig-like glycoprotein expressed by the majority of circulating natural killer cells and γδ T cells. Whether CD160 could regulate CD8 + T-cell functions remains unknown. In this study, we investigated the effects of CD160 on CD8 + T cells in pancreatic cancer.
共信号分子CD160的结构功能、信号网络及其在人类疾病中作用的 …
糖基磷脂酰肌醇 (GPI)锚定的跨膜糖蛋白CD160作为免疫球蛋白超家族 (IgSF)成员,可通过与自然杀伤 (NK)细胞和T细胞作用影响机体免疫功能。 根据是否存在免疫球蛋白 (Ig)结构域和细胞膜表面锚定方式的差异,CD160分子可被分为4种异构体。 CD160与其配体疱疹病毒进入介质 (HVEM)形成的CD160-HVEM复合体是IgSF和肿瘤坏死因子受体超家族 (TNFRSF)间直接相互作用的特例,并且根据靶细胞的不同,CD160-HVEM复合体可产生共刺激或共抑制信号,从而调控免疫应答 …
CD160: a unique activating NK cell receptor - PubMed
2011年8月30日 · Here we discuss CD160 an essential NK cell activating receptor that remains poorly understood. CD160 receptor exhibits a number of unique structural and functional characteristics that are not common to other killer immunoglobulin-like receptors that recognize major histocompatibility complex (MHC) …
CD160 protein as a new therapeutic target in a battle against
2021年11月15日 · CD160 has a significant impact on the proper functioning of the immune system by activating natural killer cells and inhibiting T cells. CD160 is a natural ligand for herpes virus entry mediator (HVEM), a member of the tumor necrosis factor superfamily.
CD160分子(CD160)|ELISA指标 - 百家号
2024年9月19日 · CD160是糖基磷脂酰肌醇锚定蛋白,属IgSF成员,影响免疫功能,作为MHCI类分子受体参与免疫调节。 广泛表达于多种免疫细胞,以GPI锚定和跨膜形式存在,启动不同信号通路。 CD160分子(CD160),也被称为BY55,是一种糖基磷脂酰肌醇(GPI)锚定蛋白,属于免疫球蛋白超家族(IgSF)成员。 CD160是一种27kDa的糖蛋白。 它的表达与外周血NK细胞和具有细胞溶解作用的CD8 T淋巴细胞密切相关。 它的cDNA序列预测是一个富含半胱氨酸、糖基磷 …
CD160 - an overview | ScienceDirect Topics
CD160 is an activating receptor expressed in the CD56dim CD16 + cytotoxic NK subset that constitutes the major NK fraction in circulating human NK cells (Figure 9.3) [69,70]. Engagement of CD160 recruits PI3K to activate the lytic cascade [71]. Both glycosylphosphatidylinositol (GPI)-anchored and transmembrane isoforms are found on NK cells.
CD160 分子(CD160)基因 | MCE - MCE-生物活性分子大师
CD160 是一种 27 kDa 的糖蛋白,最初是用单克隆抗体 BY55 鉴定的。 其表达与外周血 NK 细胞和具有溶细胞效应活性的 CD8 T 淋巴细胞密切相关。 CD160 的 cDNA 序列预测富含半胱氨酸的糖基磷脂酰肌醇锚定蛋白,由 181 个氨基酸组成,具有与 KIR2DL4 分子弱同源的单个 Ig 样结构域。 CD160 在细胞表面表达为紧密二硫键连接的多聚体。 RNA 印迹分析显示 1.5 和 1.6 kb 的 CD160 mRNA,其表达高度限于循环 NK 和 T 细胞、脾脏和小肠。
CD160 inhibits activation of human CD4 - Nature
2008年1月13日 · Here we show that CD160 expression was increased after activation of human CD4 + T cells and that crosslinking CD160 with monoclonal antibody strongly inhibited CD3- and CD28-mediated...