Aug 11, 2020 · CD146 was originally identified as a melanoma cell adhesion molecule (MCAM) and highly expressed in many tumors and endothelial cells.

CD146 (cluster of differentiation 146) is an adhesion molecule that is expressed by different cells constituting vessels, particularly endothelial cells. The last 30 years of research in this field have shown that CD146 plays a key role in the control of several vessel functions.

Apr 18, 2019 · CD146 (cluster of differentiation 146) expression. CD146 is highly present at the junction but outside tight and adherent junctions. CD146 is a transmembrane glycoprotein that contains 5 immunoglobulin-like domains.

Because of the heterogeneity of CD146 expression in MSC populations, we compared CD146 −/Low and CD146 High cells from clonal and sorted MSCs after culture expansion to determine whether this expression is associated with specific functions.

Apr 28, 2013 · CD146 has increasingly become an important molecule, especially identified as a novel bio-marker for angiogenesis and for cancer. Here we have reviewed the dynamic research of CD146, particularly newly identified functions and the underlying mechanisms of CD146.

In this study, CEC were analyzed by flow cytometry applying three different panels composed of the antibodies CD144, CD146, CD31, CD133, CD45 and anti-Vascular endothelial growth factor receptor-2 (VEGFR2), remembering that these cells can present more than one phenotype.

CD146, also known as melanoma cell adhesion molecule (MCAM), is a membrane glycoprotein and member of the immunoglobulin gene superfamily. It is normally expressed by vascular endothelial cells, smooth muscle cells, and pericytes.

CD146 (MCAM, MUC18, S-Endo1) is a transmembrane glycoprotein belonging to both CAM and mucin families. It exists as different splice variants and is cleaved from the membrane by metalloproteases to generate a soluble form. CD146 is expressed by ...

Since its identification as a marker for advanced melanoma in the 1980s, CD146 has been found to have multiple functions in both physiological and pathological processes, including embryonic development, tissue repair and regeneration, tumor progression, fibrosis …

Apr 28, 2013 · CD146 is a cell adhesion molecule (CAM) that is primarily expressed at the intercellular junction of endothelial cells. CD146 was originally identified as a tumor marker for melanoma (MCAM) due to its existence only in melanoma but not in …