The cell surface antigen CD14 is primarily understood to act as a co-receptor for toll-like receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury in macrophages and monocytes. However, roles for CD14 are increasingly ...

2024年12月24日 · CD14 (CD14 Molecule) is a Protein Coding gene. Diseases associated with CD14 include Alagille Syndrome 1 and Croup. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System. Gene Ontology (GO) annotations related to this gene include lipopolysaccharide binding and lipoteichoic acid binding.

2019年8月1日 · CD14 helps oxPAPC to be transported into cytoplasm to bind with caspase-11 and lead to NLRP3 inflammasome assembly and secretion of IL-1 and IL-18. This CD14-mediated oxPAPC endocytosis induces an inflammasome-dependent state of …

Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses. CD14 was first identified as a marker of monocytes to signal intracellular responses upon bacterial encounters.

CD14 is a glycolipid-anchored membrane glycoprotein expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. CD14 is a key molecule in the activation of innate immune cells and exists as a membrane-anchored or soluble form.

2023年12月1日 · CD14 is a co-receptor of Toll-like receptor (TLR)− 4, with a critical role in innate immune responses. CD14 recognizes bacterial lipopolysaccharides, pathogen-, and damage-associated molecular patterns, thereby facilitating inflammatory immune responses.

2013年7月23日 · CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor known to serve as a co-receptor for several Toll-like Receptors (TLRs) both at the cell surface and in the endosomal compartment. CD14 can be expressed by cells of both hematopoietic and non-hematopoietic origin as a cell membrane or secreted protein.

Here, CD14 function, its expression in different cell types and the regulation of expression, including the generation of soluble CD14, are described, and the diagnostic value of CD14 in various diseases is discussed.

Analysis of CD14 + CD16 + monocytes by scRNA-seq identifies nine clusters with one group of clusters exhibiting an increased migratory and inflammatory phenotype. Human CD14 + monocytes were isolated from leukopaks and cultured non-adherently with M-CSF in vitro for three days to obtain mature CD14 + CD16 + monocytes, followed by cryopreservation for …

cd14 — мембранный гликозилфосфатидилинозитол-связанный белок, экспрессированный на ...