Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth …

2022年6月9日 · CD117 is a proto-oncogene activated in GIST tumors, receptor for kit protein, a 145 kD tyrosine kinase growth factor receptor protein

CD117 is a type of receptor tyrosine kinase and a type of tumor marker. Also called c-kit and stem cell factor receptor. A protein found on the surface of many different types of cells. It binds to a …

CD117 is present on approximately 4% of normal bone marrow mononuclear cells and in acute myelogenous leukemia (AML) and chronic myelogenous leukemia in myeloid blast crisis, but …

CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the stem cell factor.

CD117, also known as c-kit, is a tyrosine kinase receptor that is expressed in most hemopoietic stem and progenitor cells, as well as mast cells. It is a marker used for the detection of mast …

CD117, also known as c-kit, is a protein that acts as a receptor on the surface of specific cells in the body. It is involved in cell growth, survival, and development, particularly in cells that form …

CD117, the c-kit proto-oncogene product, is expressed in subsets of hematopoietic stem cells, mast cells, melanocytes, and interstitial cells of Cajal of the GI tract. CD117 was almost …

2019年11月13日 · The CD117 (c-KIT) receptor tyrosine kinase is expressed on the cell surface of hematopoietic stem cells and its signaling is important in cell survival, proliferation and …

2019年2月6日 · Here we show that a single dose of a CD117-antibody-drug-conjugate (CD117-ADC) to saporin leads to > 99% depletion of host HSCs, enabling rapid and efficient donor …