CD1（分化簇1）分为CD1a（R4），CD1b（R2），CD1c（R7），CD1d（R3）和CD1e（R2）五种。 它们与MHCⅠ类分子的结构相似，可以提呈脂质或者糖脂质的抗原。 另外，NKT细胞也只能接受由CD1d递呈的抗原。

CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.

CD分子，又称 分化簇 （Cluster of Differentiation）或分化群，也叫 白细胞分化抗原，是不同谱系的白细胞在正常分化成熟的不同阶段及活化过程中，出现或消失的细胞表面标记。 CD分子对于机体的免疫反应十分重要，广泛分布于B细胞、T细胞、树突状细胞和NK细胞等免疫细胞的表面。 随着淋巴细胞的成熟，细胞表面表达不同的蛋白受体，有助于确定细胞类型和成熟阶段。 文末可下载完整的CD1-CD371分子功能表。 CD分子命名系统是1982年在巴黎举行的第一届国际人类白 …

cd1a蛋白是一种跨膜蛋白，属于cd1家族，它在免疫系统中发挥重要作用。cd1家族包括cd1a、cd1b、cd1c和cd1d，它们与抗原呈递和t细胞免疫反应密切相关：与经典的主要组织相容性复合物（mhc）相比，cd1蛋白在抗原呈递…

CD1 molecules present foreign and self lipids to diverse T cells and natural killer T (NKT) cells. Whereas the clonally restricted diverse T cells mediate adaptive immunity to microbial lipid...

本人cd抗原表是cd分子的完全指南。其中的列表中全面收录了从cd1到cd363靶标，并详细列举了各个靶标的别名，细胞表达和功能。使白细胞表面抗原分类一目了然。

cd1 (分化簇1）是分布于不同抗原提呈细胞（apc）表面的一类糖蛋白，在人类，其编码基因位于1号染色体。这类蛋白质分子与mhc1（第一类主要组织相容性复合体）有同源关系，参与将脂质抗原提呈给t淋巴细胞 [1] 。然而，cd1的确切作用至今仍不明确。

CD1 molecules are cell surface glycoproteins expressed mainly by white blood cells, including B lymphocytes, macrophages and dendritic cells (DC). They consist of two chains: β 2 microglobulin (β 2 m), also found in MHC class I molecules, and a heavy chain containing three extracellular domains (α1–α3).

首先，CD代表cluster of differentiation，也就是说，大多数CD系列的蛋白和细胞分化信号有关。 CD1包括5个成员，和细胞的抗原递呈有关。 1a由T细胞，树突状细胞的部分亚群表达；1b介导了部分gammadelta T细胞对细菌脂质抗原（尤其是格兰仕阴性菌）的识别；1c介导了微生物的糖脂和脂质抗原对T细胞的递呈；1d研究的比较多，介导了脂质抗原递呈到NKT细胞，包括CD1d+的B细胞，系统性或B细胞缺失CD1d的小鼠呈现自身免疫疾病并且有大量的致病性的T细胞激活，提 …

The human cluster of differentiation (CD)1 system for antigen display is comprised of four types of antigen-presenting molecules, each with a distinct functional niche: CD1a, CD1b, CD1c, and CD1d. Whereas CD1 proteins were thought solely to ...

Here, we summarize the molecular properties of the CD1 isoforms, their lipid antigens, and CD1-restricted T cells, with particular focus on CD1a. We then discuss the roles that CD1a-reactive T cells play in several diseases.

This review summarizes the major features of CD1 genes and proteins, the patterns of intracellular trafficking of CD1 molecules, and how they sample different intracellular compartments for self- and foreign lipids. We describe how lipid antigens bind to CD1 molecules with their alkyl chains buried …

CD1 molecules are well known for their role in binding and presenting lipid antigens to mediate the activation of CD1-restricted T cells. However, much less appreciated is the fact that CD1 molecules can have additional “unconventional” roles which ...

2017年10月30日 · The human cluster of differentiation (CD)1 system for antigen display is comprised of four types of antigen-presenting molecules, each with a distinct functional niche: CD1a, CD1b, CD1c, and CD1d. Whereas CD1 proteins were thought solely to influence T-cell responses through display of amphipathic l …

2003年6月1日 · In this review we outline the functionally distinct subsets of CD1-restricted T cells and the pathways by which CD1-reactive T cells are activated and carry out their effector functions.

CD1 molecules are glycoproteins composed of a heavy chain noncovalently linked to beta-2 microglobulin (β 2 m), similar to MHC class I. Unlike MHC class I, however, CD1 molecules have evolved hydrophobic channels for binding hydrocarbon alkyl chains, and have cytoplasmic tails that target them to distinct endocytic compartments.

The CD1 proteins are a family of non-polymorphic, MHC class I-related molecules that present lipid antigens to subsets of T lymphocytes with innate- or adaptive-like immune functions. Recent studies have provided new insight into the identity of ...

The CD1 molecules bind and present amphipathic lipid antigens for recognition by T-cell receptors. Here, we outline the recent advances in our understanding of how the processes of CD1 assembly, trafficking, lipid-antigen binding and T-cell activation are achieved and the new insights into how lipid antigens differentially elicit CD1-restricted ...

2024年6月4日 · Discover the crucial role of CD1 in the immune system. Learn how CD1 molecules present lipid antigens, aid in immune surveillance, and regulate responses to pathogens and diseases.

2022年12月13日 · We discuss new themes regarding antigen presentation by CD1 and MR1 and modes of antigen recognition by CD1- and MR1-restricted T cell receptors (TCRs). We highlight recent work on how these cells develop and underscore the growing appreciation of the role of the microbiota in the biology of these cells.