CD9 is a gene encoding a protein that is a member of the transmembrane 4 superfamily also known as the tetraspanin family. It is a cell surface glycoprotein that consists of four transmembrane regions and has two extracellular loops that contain disulfide bonds which are conserved throughout the tetraspanin family.

2024年12月24日 · CD9 (CD9 Molecule) is a Protein Coding gene. Diseases associated with CD9 include Diphtheria and Acquired Immunodeficiency Syndrome . Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Uptake and actions of bacterial toxins .

2018年10月8日 · CD9 belongs to the tetraspanin superfamily. Depending on the cell type and associated molecules, CD9 has a wide variety of biological activities such as cell adhesion, motility, metastasis, growth, signal transduction, differentiation, and sperm–egg fusion.

The tetraspanin CD9 is expressed by all the major subsets of leukocytes (B cells, CD4 + T cells, CD8 + T cells, natural killer cells, granulocytes, monocytes and macrophages, and immature and mature dendritic cells) and also at a high level by endothelial cells.

2025年2月8日 · Transmembrane protein CD9 is glioblastoma biomarker, relevant for maintenance of glioblastoma stem cells. Podergajs N, et al. Oncotarget, 2016 Jan 5. PMID 26573230, Free PMC Article. CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells. Nishida H, et al. Biochem Biophys Res Commun, 2009 Apr 24. PMID 19254692

2025年2月8日 · CD9, a potential leukemia stem cell marker, regulates drug resistance and leukemia development in acute myeloid leukemia. Genetic Predisposition to Colon and Rectal Adenocarcinoma Is Mediated by a Super-enhancer Polymorphism Coactivating …

2018年4月30日 · The tetraspanin CD9 is expressed by all the major subsets of leukocytes (B cells, CD4 + T cells, CD8 + T cells, natural killer cells, granulocytes, monocytes and macrophages, and immature and mature dendritic cells) …

2018年10月9日 · CD9 belongs to the tetraspanin superfamily. Depending on the cell type and associated molecules, CD9 has a wide variety of biological activities such as cell adhesion, motility, metastasis, growth, signal transduction, differentiation, and sperm-egg fusion.

CD9, a 24 kDa tetraspanin membrane protein, is known to regulate cell adhesion and migration, cancer progression and metastasis, immune and allergic responses, and viral infection. CD9 is upregulated in senescent endothelial cells, neointima hyperplasia, and atherosclerotic plaques.

2024年3月1日 · CD9, a potential leukemia stem cell marker, regulates drug resistance and leukemia development in acute myeloid leukemia. Liu Y, Wang G, Zhang J, Chen X, Xu H, Heng G, Chen J, Zhao Y, Li J, Ni Y, Zhang Y, Shan J, Qian CLiu Y, et al. Stem Cell Res Ther, 2021 Jan 25. PMID 33494824.