CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils [6] and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a …

Aug 5, 2019 · CD24，全称为cluster of differentiation 24，又称热稳定抗原，是一种高度糖基化的糖基磷脂酰肌醇锚定表面蛋白，已知与先天免疫细胞上的 Siglec-10 （sialic-acid-binding Ig-like lectin10）相互作用，以抑制响应感染、败血症、肝损伤和慢性移植物抗宿主疾病的破坏性炎症反应。

1978年，科学家首次发现CD24，即分化簇24（Cluster of differentiation 24），也称为热稳定抗原（heat-stable antigen，HSA)，一种高度糖基化的糖基磷脂酰肌醇 (GPI)锚定的膜蛋白。 CD24没有胞内信号结构域，然而，…

Nov 2, 2023 · Cluster of differentiation 24 (CD24), a mucin-like highly glycosylated molecule has been extensively studied as a cancer stem cell marker in a variety of solid cancers. The functional role of CD24 is either fulfilled by combining with ligands or participating in signal transduction, which mediate the initiation and progression of neoplasms.

Dec 24, 2024 · CD24 (CD24 Molecule) is a Protein Coding gene. Diseases associated with CD24 include Erythroleukemia and Multiple Sclerosis. Among its related pathways are Nervous system development and L1CAM interactions. Gene Ontology (GO) annotations related to this gene include protein kinase binding and carbohydrate binding.

CD24, is a mucin-like GPI-anchored molecules. By immunohistochemistry, it is widely detected in many solid tumors, such as breast cancers, genital system cancers, digestive system cancers, neural system cancers and so on.

Feb 15, 2010 · In the adaptive immune response, CD24 is a redundant costimulatory molecule in costimulation-rich lymphoid organs but is essential in selected target organs tested, such as...

Genetic ablation and therapeutic blockade of CD24 resulted in a macrophage-dependent reduction of tumour growth in vivo and an increase in survival time. These data reveal CD24 as a highly expressed, anti-phagocytic signal in several cancers and demonstrate the therapeutic potential for CD24 blockade in cancer immunotherapy.

Jul 31, 2019 · We demonstrate a role for tumour-expressed CD24 in promoting immune evasion through its interaction with the inhibitory receptor sialic-acid-binding Ig-like lectin 10 (Siglec-10), which is...

Jan 13, 2021 · CD24-Fc是由OncoImmune公司的华人科学家刘阳教授多年的研究成果，于2020年11月23日被默沙东以4.25亿美元预付款进行收购，这一合作金额也打破了License-out的纪录。 在这里，我们对CD24的结构、CD24与肿瘤、CD24-Siglec信号通路及CD24-Fc免疫疗法进行介绍。 CD24的结构与功能. 细胞粘附分子是参与细胞间、细胞与细胞外基质间相互作用的分子，细胞粘附是细胞间信息交流的一种方式，其中作为信息交流的可溶介质成为细胞粘附分子（CAM, cell …