CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling.

2021年7月21日 · CD22 presents an attractive target in lymphoid neoplasms given its unique presence in B-lymphocytes. Due to its role in regulating B-cell function, CD22 has also been targeted in autoimmune diseases such as systemic lupus erythematosus and Sjogren syndrome.

CD22 is a member of the immunoglobulin gene super-family. It is involved in the regulation of expression of surface IgM on B cells. Cytoplasmic CD22 is expressed at the earliest stages of B-cell differentiation, along with CD19 and is present prior to the expression of CD20.

2018年9月27日 · CD22 (Siglec 2) is a receptor predominantly restricted to B cells. It was initially characterized over 30 years ago and named “CD22” in 1984 at the 2nd International workshop in Boston (1). Several excellent reviews have detailed CD22 functions, CD22-regulated signaling pathways and B cell subsets regulated by CD22 or Siglec G (2 – 4).

2012年10月31日 · In characterizing the antitumor activity of an established anti-CD22 monoclonal antibody (mAb), HB22.7, we showed CD22 expression by multiple approaches in various lung cancer subtypes, including 7 of 8 cell lines and a panel of primary patient specimens.

CD22 is an inhibitory coreceptor of the B-cell receptor (BCR), and plays a critical role in establishing signalling thresholds for B-cell activation.

2017年10月2日 · CD22 maintains a baseline level of B-cell inhibition to keep humoral immunity in check. As a B-cell-restricted antigen, CD22 is targeted in therapies against dysregulated B cells that cause...

2023年10月11日 · CD22-targeted therapies, mainly including the antibody–drug conjugates (ADCs) and CAR-T cells, have come into wide clinical use with acceptable toxicities and promising efficacy.

2024年12月24日 · CD22 (CD22 Molecule) is a Protein Coding gene. Diseases associated with CD22 include Hematologic Cancer and Trichomoniasis. Among its related pathways are Antigen activates B Cell Receptor (BCR) leading to generation of second messengers and Regulation of activated PAK-2p34 by proteasome mediated degradation.

Describes cells that have a protein called CD22 on their surface. CD22 is found mostly on B cells (a type of white blood cell) and controls many important cell functions, including cell signaling, cell adhesion, cell growth, and cell survival. CD22 is also found on many B-cell leukemia and lymphoma cells.