Because the CD40–CD40L interaction can be antagonized with mAbs against either CD40L or CD40, antagonizing CD40 seems a more attractive approach. A blocking anti-CD40 mAb has shown promising results in a small open label phase I/IIa study in CD patients without serious side effects [54]. The therapeutic benefit by antagonizing CD40 may ...

2010年2月1日 · BCL-1 (cyclin D1) is a proto-oncogene involved in regulation of the cell cycle. Rearrangement of this gene as seen in 1(11,14)(q13:q32) is associated with certain B-cell lymphomas, such as mantle cell lymphoma and a subclass of plasma-cell myeloma with overexpression of BCL-1 protein in these tumors.

Microglial physiology and function. Alexei Verkhratsky, Arthur M. Butt, in Neuroglia, 2023. 3.2.4 CD11b protein. The CD11b protein (also known as integrin α-M, CD11b/CD18, MO1 or Mac-1) is a component of complement receptor 3. 51 This protein is expressed in immune cells, where it mediates many functions, including cell adhesion, migration and phagocytosis. 52 The clone …

The leukocyte integrin CD11c is a myeloid marker expressed on most DCs (Table 1).CD11c + DCs can be further subdivided by their expression of CD8α, the alpha chain of the T-cell co-receptor CD8 (see [2] for a recent review of DCs).

In B and T cells, all CD11/CD18-dependent functions – such as mitogen, antigen, and alloantigen-induced proliferation, T cell-mediated cytotoxicity, B cell aggregation, and Ig production – are inhibited by anti-LFA-1 mAbs.

By contrast, in the mouse, long-term repopulating activity is present in the CD34 −/low fraction but not in the CD34 + fraction of adult bone marrow cells. 3 HSCs in the aorta–gonads–mesonephros region and fetal liver are, however, known to express CD34 antigen. 10, 11 Therefore, the expression of CD34 antigen on HSCs is developmentally ...

Anti-adhesion antibodies. Russell L Dedrick, ... Marvin Garovoy, in Transplant Immunology, 2002. CD11a is an attractive therapeutic target for T cell-mediated disorders because of its key roles in: (1) binding to inflamed vascular endothelium; (2) trafficking through the endothelial layer into underlying tissue; and (3) adhesion and co-stimulatory interactions with antigen presenting cells.

CD11c is a type I transmembrane protein that is expressed on monocytes, granulocytes, a subset of B cells, dendritic cells, and macrophages and may be demonstrated on B-cell chronic lymphocytic leukemia, marginal zone lymphomas, and hairy cell leukemia.

2021年10月1日 · The desorption efficiency of Cd(II) and Pb(II) ions exhibited a negligible decrease after five cycles and reached 82 and 85 for Cd(II) and Pb(II) ions, respectively. The good recyclability of BC-Thioamide/MNPs indicated that this sorbent can be used as an effective, recyclable and economic adsorbent in practical treating of metal-polluted ...

HMGB1 acts as a ligand for TLR2, TLR4, TLR9, RAGE, CD24, Siglec-10 (Siglec-G in mice), and Mac-1 [macrophage-1 antigen (complement receptor consisting of CD11b and CD18)] 7–11 and has diverse proinflammatory roles through interactions with these different receptors. For example, HMGB1 signaling through RAGE mediates chemotaxis, proliferation ...