Cyclin E1 - Wikipedia
G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene. [5] The protein encoded by this gene belongs to the highly conserved cyclin family, whose members …
CCNE1 amplification is synthetic lethal with PKMYT1 kinase …
Apr 20, 2022 · To uncover therapeutic targets for tumours with CCNE1 amplification, we undertook genome-scale CRISPR–Cas9-based synthetic lethality screens in cellular models of …
CCNE1 Gene - GeneCards | CCNE1 Protein | CCNE1 Antibody
Dec 24, 2024 · CCNE1 (Cyclin E1) is a Protein Coding gene. Diseases associated with CCNE1 include Pancreatic Cancer and Ovarian Cancer. Among its related pathways are Regulation of …
CCNE1 copy number is a biomarker for response to ... - Cell Press
These studies demonstrate that CCNE1 CN is a clinically tractable biomarker predicting responsiveness to low-dose WEE1i-ATRi for aggressive subsets of OVCAs/EMCAs. …
CCNE1 Amplification as a Predictive Biomarker of Chemotherapy ...
May 5, 2020 · Here, we review the current understanding of one of the most common genetic alterations in epithelial ovarian cancer, CCNE1 (cyclin E1) amplification, and its role as a …
Prognostic Values of CCNE1 Amplification and Overexpression in …
A number of studies revealed that CCNE1 copy number amplification and overexpression (on mRNA or protein expression level) were associated with prognosis of diverse cancers, …
CCNE1 is a predictive and immunotherapeutic indicator in various ...
Mar 24, 2023 · Our study demonstrated that CCNE1 is upregulated in multiple cancers in the TCGA database and may be a promising predictive biomarker for the immunotherapy …
898 - Gene ResultCCNE1 cyclin E1 [ (human)] - National Center for ...
Feb 9, 2025 · CCNE1 Is a Putative Therapeutic Target for ARID1A-Mutated Ovarian Clear Cell Carcinoma. Cyclin E1 expression and malignancy in meningiomas. Reduced RBX1 expression …
CCNE1 cyclin E1 [Homo sapiens (human)] - Gene - NCBI
Feb 9, 2025 · Title: PKMYT1: A Potential Target for CCNE1 Amplificated Colorectal Tumors. Long noncoding RNA LINC02568 sequesters microRNA-874-3p to facilitate malignancy in breast …
Molecular landscape and clinical implication of CCNE1-amplified ...
Jan 24, 2023 · Background: Cyclin E1 (CCNE1) amplification (CCNE1 Amp) drives chromosomal instability (CIN) and is associated with immune cell exclusion, liver metastasis, therapeutic …