2024年12月24日 · CCL5 (C-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.

CCL5/CCR5 axis promotes VEGF production by attracting endothelial progenitor cells (EPCs). The CCL5-overexpressing-osteosarcoma makes EPCs migrate to abnormal sites.

2024年9月27日 · Our findings demonstrate the significant potential of CCL5 as an immunotherapeutic response biomarker and prognostic indicator, which may pave the way for more studies on the mechanism of tumor...

Introduction: Chemokines play important roles in inflammation and in immune responses. This article will discuss the current literature on the C–C chemokine ligand 5 (CCL5), and whether it is a therapeutic target in the context of various allergic, autoimmune or infectious diseases.

CCL5 (also RANTES) is a chemokine that provides activating and chemotactic signalling to T lymphocytes, basophils and eosinophils of the peripheral immune system (Murphy et al., 2000). In the CNS, CCL5 is constitutively expressed by microglia …

2021年6月9日 · CCL5，CC类趋化因子配体5，也称为调节激活正常T细胞表达分泌因子（RANTES），是一种能使白细胞作定向移动的小分子分泌蛋白。 CCL5来源广泛，如NK、T、巨噬细胞、滑膜成纤维细胞，炎症反应中的CD8+ T细胞、上皮细胞、成纤维细胞和血小板，病毒感染后的细胞，以及某些肿瘤细胞。 CD40、IL-15等不同刺激物激活NF-kB会诱导CCL5的产生。 …

CCL5's Role in Periodontal Disease: A Narrative Review. Low peripheral blood chemokine (C-C motif) ligand 5 and tumor necrosis factor alpha gene expression is associated with unfavorable progression of respiratory syncytial virus bronchiolitis in infants.

2021年4月30日 · CCL5 promotes aerobic glucose metabolism, mitochondrial ATP generation and purine synthesis, improving synaptic plasticity and enhancing memory and cognition functions.

2025年2月8日 · It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

2024年9月17日 · CCL5 plays a critical role in starting the intrinsic neuronal regeneration system following TBI, which includes growth cone formation, axonogenesis and synaptogensis, remyelination, and the subsequent proper wiring of cortical circuits.