Inflammation plays an important role in aging. C-C chemokine receptor 9 (CCR9) and its ligand C-C chemokine ligand 25 (CCL25) are involved in the regulating the occurrence and development of various diseases, which has become a research hotspot.

CCL25, also known as TECK, is a chemokine that is unusually long and highly expressed in the thymus and small intestinal epithelium. It binds to the unique receptor CCR9, which is expressed on specific T cells.

Recent in vivo studies have demonstrated a role for CCL25/CCR9 in mediating lymphocyte recruitment to the small intestine and in the development of the small intestinal T-cell receptor-gammadelta T-cell compartment.

Multiple studies have confirmed that chemokine receptor 9 (CCR9) and its exclusive ligand, chemokine 25 (CCL25), are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, apoptosis, invasion, migration and drug resistance.

2024年12月24日 · CCL25 (C-C Motif Chemokine Ligand 25) is a Protein Coding gene. Diseases associated with CCL25 include Ileitis and Cholangitis, Primary Sclerosing . Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway .

CCL25 is an antimicrobial protein with bacteriocidal activity against E. coli and S. aureus. CCL25 and CCR9 regulate colorectal cancer progression and invasion.

2021年8月19日 · Inflammation plays an important role in aging. C-C chemokine receptor 9 (CCR9) and its ligand C-C chemokine ligand 25 (CCL25) are involved in the regulating the occurrence and development of various diseases, which has become a research hotspot.

The CC chemokine receptor 9 (CCR9) and its natural secreted ligand CC motif chemokine ligand 25 (CCL25) have been implicated in cancer metastasis. However, their metastatic potential in non-small cell lung cancer (NSCLC) remains unclear. In the ...

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1.

We found that inhibition of CCL25 significantly reduced inflammatory cytokine expression in a CLP-induced sepsis model, thereby alleviating lung tissue damage in mice. Our study suggests that CCL25 contributed to the development of ALI by modulating the functions of microvascular endothelial cells.