Small intestine: chromogranin c-kit / CD117 DOG1 Ki67 synaptophysin Stomach: chromogranin c-kit / CD117 claudin 18.2 (pending) DOG1 desmin EBER1 / 2 / LMP gastrin (pending) …

Mar 11, 2025 · KIT is the gene encoding a transmembrane tyrosine kinase receptor, involved in both the MAP kinase and AKT pathways, which are intimately involved with cell proliferation …

Sep 21, 2020 · Well circumscribed lesion; usually no pseudocapsule, tumor directly abuts the renal parenchyma (Am J Surg Pathol 1997;21:1, J Kidney Cancer VHL 2017;4:1)

Sep 2, 2021 · Monoclonal (SP31, K9, DOG1.1) and polyclonal antibodies (Cancer Control 2015;22:498) Most sensitive and specific marker for GIST

May 24, 2022 · Unfavorable prognostic features: Clinical: ↑ age, ↑ LDH, Eastern Cooperative Oncology Group (ECOG) ≥ 2, Ann Arbor stage III / IV, extranodal disease, bulky disease (J …

Feb 16, 2022 · However, due to the lack of sensitivity and specificity and emerging utility for PAX8, CAIX, CK7 and CD117 (c-kit), RCC has become less commonly used by pathologists …

Apr 16, 2024 · Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare adnexal tumor with different histopathologic growth patterns, including cribriform, tubular and solid variants

Dec 17, 2024 · PAX8 (100%) ; TFE3 (95%) . Very high sensitivity; positive in 95% of cases Should be used with cautious interpretation given that it can be overexpressed in other tumor …

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However, GISTs are uniformly c-kit positive and usually CD34 positive. The differential diagnosis also includes fibroblastic reticulum cell sarcoma (vimentin+, smooth muscle actin+, desmin+, …