BTLA is a 289 amino acid long transmembrane glycoprotein. It is very similar in structure to PD-1 and CTLA-4. Therefore, it consists of an extracellular domain, a transmembrane domain and a …

2021年3月29日 · B and T lymphocyte attenuator (BTLA) is one of the most important cosignaling molecules. It belongs to the CD28 superfamily and is similar to programmed cell death-1 (PD …

2021年3月28日 · BTLA can be detected in most lymphocytes and induces immunosuppression by inhibiting B and T cell activation and proliferation. The BTLA ligand, herpesvirus entry mediator …

2024年1月17日 · This review aims to provide an in-depth understanding of BTLA’s biology, its role in various cancers, and its potential as a prognostic factor. Additionally, it explores the latest …

2024年12月24日 · BTLA (B And T Lymphocyte Associated) is a Protein Coding gene. Diseases associated with BTLA include Hematologic Cancer and Rheumatoid Arthritis. Among its …

Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs.

Checkpoint receptors, such as B and T lymphocyte attenuator (Btla), are widely expressed in lymphocyte and myeloid cells, where they function to regulate innate and adaptive immune …

2025年2月8日 · Gene ID: 151888, updated on 8-Feb-2025. This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) …

2022年3月22日 · Together our studies provide important insights into how Btla functions as a checkpoint in diverse conventional and regulatory lymphocyte subsets to influence systemic …

WHAT THIS STUDY ADDS This study shows that BTLA promoter hypomethylation leads to increased BTLA mRNA and protein expression, higher immune cell infiltration, and better …

2008年9月1日 · The recently described receptor, B and T Lymphocyte Attenuator (BTLA), has been demonstrated to have an important role in limiting the duration of inflammation in a …

As demonstrated in in vitro studies, BTLA has a direct negative activity on T cell proliferation and cytokine production. Moreover, BTLA is an inhibitory co-receptor of the BCR signaling pathway …

The B and T lymphocyte attenuator, BTLA, is a recently discovered Ig superfamily member. BTLA engagement results in downregulation of T-cell activation, and mice deficient in BTLA show …

2022年3月22日 · Stienne et al. investigate how BTLA and HVEM receptors control inflammatory and metabolic signaling in lymphocytes. A major function of these receptors in intestinal …

2003年6月8日 · Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin domain–containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs.

In cancer, abnormal cells evade immune surveillance by exploiting checkpoints like BTLA. Upregulated BTLA expression is linked to impaired anti-tumor immunity and unfavorable …

2021年8月31日 · BTLA (B- and T- Lymphocyte Attenuator) is a co-inhibitory receptor mainly expressed by B and T cells, repressing the activation signal transduction. BTLA shares …

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2006年6月16日 · The B and T lymphocyte attenuator (BTLA/CD272) is a third member of co-inhibitory receptors, which belongs to the CD28 immunoglobulin-superfamily. Using …

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