2024年12月24日 · BRF2 (BRF2 General Transcription Factor IIIB Subunit) is a Protein Coding gene. Diseases associated with BRF2 include Prostate Cancer and Cone-Rod Dystrophy 9 . Among its related pathways are RNA Polymerase III …

2015年12月3日 · TFIIB-related factor 2 (Brf2) is a member of the family of TFIIB-like core transcription factors. Brf2 recruits RNA polymerase (Pol) III to type III gene-external promoters, including the U6 spliceosomal RNA and selenocysteine tRNA genes. Found only in vertebrates, Brf2 has been linked to tumorigenesis but the underlying mechanisms remain elusive.

2015年12月3日 · Direct redox-sensing by the RNA polymerase III core transcription factor Brf2 couples cellular responses to oxidative stress and regulation of transcriptional output, contributing to the ability of cancer cells to evade death induced by reactive oxygen species.

2025年2月8日 · High expression of BRF2 is closely associated with tumor progression, angiogenesis, and poor survival in esophageal squamous cell cancer. BRF2 can serve as a marker for lung squamous cell carcinoma and may provide a novel target for therapy.

2021年7月27日 · BRF2, a subunit of the RNA polymerase III transcription complex, is upregulated in a wide variety of cancers and is a potential therapeutic target; however, no effective drugs are available to target BRF2. The upregulation of BRF2 in cancer cells confers survival via the prevention of oxidative stress-induced apoptosis.

2015年12月3日 · Brf2 recruits RNA polymerase (Pol) III to type III gene-external promoters, including the U6 spliceosomal RNA and selenocysteine tRNA genes. Found only in vertebrates, Brf2 has been linked to tumorigene …

Recently, BRF2, a component of TFIIIB required for gene external RNA pol III transcription, was identified as an oncogene in squamous cell carcinomas of the lung through integrative genomic analysis. In this review, we focus on recent advances demonstrating how BRF2-TFIIIB mediated transcription is regulated by tumor suppressors and oncogenes.

Deregulation of the RNA polymerase III specific TFIIIB subunit BRF2 occurs in subtypes of human cancers. However, correlations between BRF2 alterations and clinical outcomes in breast cancer are limited. We conducted this review to analyze BRF2 ...

2021年7月27日 · The overexpression of BRF2, a selective subunit of RNA polymerase III, has been shown to be crucial in the development of several types of cancers, including breast cancer and lung squamous cell carcinoma. Predominantly, BRF2 acts as a central redox-sensing transcription factor (TF) and is involved …

brf2 rna 聚合酶 iii 转录起始因子亚基： 该基因编码 rna 聚合酶 iii 转录因子复合物的多个亚基之一，该复合物是转录具有起始位点上游启动子元件的基因所必需的。