BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes—one copy inherited from each parent.

乳腺癌一号基因 （BRCA1）是一种 蛋白质，由在人体中编码为BRCA1的基因组成 [6]，BRCA1是人类 肿瘤抑制基因，负责修复 DNA。 BRCA1与 BRCA2 是两种不相关的蛋白质 [7]，但通常都在乳房与其他细胞组织中出现。 它们可帮助修复DNA，也可在无法修复DNA的情况下破坏细胞。 它们参与染色体损伤的修复，在DNA双链断裂的无错修复中起着重要作用 [8]。 如果BRCA1或BRCA2本身因BRCA突变而受损，则受损的DNA无法正确修复，这会增加患乳腺癌的风险 [8] …

乳腺癌易感基因 (breast cancer susceptibility gene, BRCA)与乳腺癌有着密不可分的关系。 BRCA基因 的两个成员，即BRCA1和2，分别是在1990年和1994年被分离。 乳腺癌可以分为 遗传性乳腺癌 和 散发性乳腺癌 (sporadic breast cancer)，散发性乳腺癌指的是没有发现明确的遗传基因改变（完整的癌变点）与乳腺癌家族史的乳腺癌。 遗传性乳腺癌占所有乳腺癌的比例大约是10-15%。 遗传性乳腺癌与BRCA基因有很大关系，45%左右的家族性乳腺癌和80%以上的遗传性 …

1990年，研究者发现了一种直接与遗传性 乳腺癌 有关的基因，命名为乳腺癌1号基因，英文简称BRCA1。 1994年，又发现另外一种与乳腺癌有关的基因，称为BRCA2。 1990年，研究者发现了一种直接与 遗传性乳腺癌 有关的基因，命名为乳腺癌1号基因，英文简称BRCA1。 1994年，又发现另外一种与乳腺癌有关的基因，称为BRCA2。 实际上，BRCA1/2是两种具有抑制 恶性肿瘤 发生的基因，在调节 人体细胞 的复制、遗传物质DNA损伤修复、细胞的正常生长方面有重要作用 …

Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiological processes.

Dec 24, 2024 · BRCA1 (BRCA1 DNA Repair Associated) is a Protein Coding gene. Diseases associated with BRCA1 include Breast-Ovarian Cancer, Familial 1 and Fanconi Anemia, Complementation Group S. Among its related pathways are Homologous DNA Pairing and Strand Exchange and Resolution of D-loop Structures through Synthesis-Dependent Strand …

BCRF’s “About Breast Cancer” resources and articles are developed and produced by a team of experts. Chief Scientific Officer Dorraya El-Ashry, PhD provides scientific and medical review. Scientific Program Managers Priya Malhotra, PhD, Marisa Rubio, PhD, and Diana Schlamadinger, PhD research and write content with some additional support. …

Sep 29, 2020 · BASC（BRCA1-Associated Genome Surveillance Complex）是BRCA1（Breast Cancer Susceptibility Protein-1）的超级复合物， 是识别和修复DNA损伤的关键。 该复合物包括肿瘤抑制因子和DNA损伤修复蛋白MSH2、MSH6、MLH1、ATM (Ataxia-Telangiectasia)、BLM(Bloom syndrome)和Rad50-MRE11(Meiotic Recombination-11)-NBS1(Nijmegen Breakage Syndrome)复合体。 此外，RFC（DNA复制因子-C）是一种蛋白质复合物，可促进PCNA加载 …

May 30, 2022 · The Borea BRA1 speakers, dedicated to the reproduction of sound effects, are an ideal complement to your home theater set-up. Thanks to their adjustable crossover, they can be used as vertical 3D effects. The speakers are placed on top of the main speakers, with the BRA1 angled up, using the sound wave reflection principle.

The Triangle Borea BRA1 Surround Speakers are built to last, with a sturdy MDF construction that minimizes unwanted vibrations and resonances. The speakers are designed to deliver superior audio quality, with a frequency response of 90 Hz to 22 kHz and a sensitivity of 89dB.