Dec 24, 2024 · BIRC2 (Baculoviral IAP Repeat Containing 2) is a Protein Coding gene. Diseases associated with BIRC2 include Glioma Susceptibility 1 and Squamous Cell Carcinoma. Among its related pathways are TNFR1 Pathway and Toll Like Receptor 7/8 (TLR7/8) Cascade.

Jul 31, 2023 · We describe the structural mechanism for targeting of BIRC2 BIR3 by a potent but biochemically uncharacterized small molecule inhibitor LCL161 and demonstrate that LCL161 disrupts the association...

Roles for the baculoviral inhibitor of apoptosis repeat-containing (BIRC) genes, BIRC2 and BIRC3, may include signaling to the inflammatory transcription factor, nuclear factor-κB (NF-κB) and protection from cell death.

Aug 25, 2020 · Here, we demonstrate a cancer-cell-intrinsic mechanism of immune evasion and resistance to ICB mediated by baculoviral IAP repeat-containing 2 (BIRC2). Knockdown of BIRC2 expression in mouse melanoma or breast cancer cells increases expression of the chemokine CXCL9 and impairs tumor growth by increasing the number of intratumoral activated CD8 ...

Aug 25, 2020 · Knockdown of BIRC2 expression (BIRC2-KD) impaired tumor growth in syngeneic mice by making the tumors more immunogenic. Most importantly, BIRC2-KD sensitized both melanoma and breast cancer to ICB.

BIRC2 and BIRC3 are closely related members of the inhibitor of apoptosis (IAP) family of proteins and play pivotal roles in regulation of nuclear factor-κB (NF-κB) signaling and apoptosis.

Jan 4, 2025 · Inhibition of BIRC2 Sensitizes alpha7-HPV-Related Cervical Squamous Cell Carcinoma to Chemotherapy. Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer. BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy.

We describe the structural mechanism for targeting of BIRC2 BIR3 by a potent but biochemically uncharacterized small molecule inhibitor LCL161 and demonstrate that LCL161 disrupts the association of endogenous BIRC2 with H3 and stimulates cell death in cancer cells.

Oct 14, 2007 · Here, we show that Birc2 (also known as cIap1) is essential for maintaining endothelial cell survival and blood vessel homeostasis during vascular development.

Sep 3, 2022 · Baculoviral IAP Repeat containing 2 (BIRC2) and Baculoviral IAP Repeat containing 3 (BIRC3) are involved in oncogenic activity by modulating cell proliferation, apoptosis and invasion in HNSCC. This study aimed to develop and validate a predictive gene signature for BIRC2 and BIRC3.