
BIRC2 Gene - GeneCards | BIRC2 Protein | BIRC2 Antibody
2024年12月24日 · BIRC2 (Baculoviral IAP Repeat Containing 2) is a Protein Coding gene. Diseases associated with BIRC2 include Glioma Susceptibility 1 and Squamous Cell Carcinoma. Among its related pathways are TNFR1 Pathway and Toll Like Receptor 7/8 (TLR7/8) Cascade.
Molecular basis for nuclear accumulation and targeting of the
2023年7月31日 · We describe the structural mechanism for targeting of BIRC2 BIR3 by a potent but biochemically uncharacterized small molecule inhibitor LCL161 and demonstrate that LCL161 disrupts the association...
Differential regulation of BIRC2 and BIRC3 expression by …
Roles for the baculoviral inhibitor of apoptosis repeat-containing (BIRC) genes, BIRC2 and BIRC3, may include signaling to the inflammatory transcription factor, nuclear factor-κB (NF-κB) and protection from cell death.
BIRC2 Expression Impairs Anti-Cancer Immunity and ... - PubMed
2020年8月25日 · Here, we demonstrate a cancer-cell-intrinsic mechanism of immune evasion and resistance to ICB mediated by baculoviral IAP repeat-containing 2 (BIRC2). Knockdown of BIRC2 expression in mouse melanoma or breast cancer cells increases expression of the chemokine CXCL9 and impairs tumor growth by increasing the number of intratumoral activated CD8 ...
BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy ...
2020年8月25日 · Knockdown of BIRC2 expression (BIRC2-KD) impaired tumor growth in syngeneic mice by making the tumors more immunogenic. Most importantly, BIRC2-KD sensitized both melanoma and breast cancer to ICB.
Oncogenic activity of BIRC2 and BIRC3 mutants independent of …
BIRC2 and BIRC3 are closely related members of the inhibitor of apoptosis (IAP) family of proteins and play pivotal roles in regulation of nuclear factor-κB (NF-κB) signaling and apoptosis.
BIRC2 baculoviral IAP repeat containing 2 [ (human)]
2025年1月4日 · Inhibition of BIRC2 Sensitizes alpha7-HPV-Related Cervical Squamous Cell Carcinoma to Chemotherapy. Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer. BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy.
Molecular basis for nuclear accumulation and targeting of the …
We describe the structural mechanism for targeting of BIRC2 BIR3 by a potent but biochemically uncharacterized small molecule inhibitor LCL161 and demonstrate that LCL161 disrupts the association of endogenous BIRC2 with H3 and stimulates cell death in cancer cells.
Birc2 (cIap1) regulates endothelial cell integrity and blood …
2007年10月14日 · Here, we show that Birc2 (also known as cIap1) is essential for maintaining endothelial cell survival and blood vessel homeostasis during vascular development.
Prognostic Significance of the BIRC2-BIRC3 Gene Signature in …
2022年9月3日 · Baculoviral IAP Repeat containing 2 (BIRC2) and Baculoviral IAP Repeat containing 3 (BIRC3) are involved in oncogenic activity by modulating cell proliferation, apoptosis and invasion in HNSCC. This study aimed to develop and validate a predictive gene signature for BIRC2 and BIRC3.
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