BAZ2A Gene - GeneCards | BAZ2A Protein | BAZ2A Antibody
Dec 24, 2024 · BAZ2A (Bromodomain Adjacent To Zinc Finger Domain 2A) is a Protein Coding gene. Diseases associated with BAZ2A include Inflammatory Spondylopathy and Alcohol-Related Birth Defects. Among its related pathways are RNA Polymerase I Promoter Opening and Gene expression (Transcription).
Pan-cancer and multi-omics analyses revealed the diagnostic and ...
Mar 4, 2024 · BAZ2A, an epigenetic regulatory factor that affects ribosomal RNA transcription, has been shown to be highly expressed in several cancers and promotes tumor cell migration. This study explored...
BAZ2A (TIP5) is involved in epigenetic alterations in prostate …
Dec 8, 2014 · Here we show that the gene encoding BAZ2A (TIP5), a factor previously implicated in epigenetic rRNA gene silencing, is overexpressed in prostate cancer and is paradoxically involved in...
体内CRISPR筛选发现BAZ2染色质重塑因子是哺乳动物肝脏再生的 …
Jan 27, 2022 · 研究人员在再生肝脏中采用了汇合CRISPR敲除和激活筛选，以评估165个染色质调节蛋白。这两种筛选方法都发现了imitation-SWI的染色质重塑成分Baz2a和Baz2b，其以前没有涉及到再生。体内sgRNA、siRNA和针对任一准分子的敲除策略证实了再生的增加。
Regulation of chromatin domains by BAZ2A - Nature Genetics
May 15, 2024 · In differentiated cells, BAZ2A associates with the long non-coding pRNA and ribosomal RNA, but is role in embryonic cells is unknown. The authors show that BAZ2A condensates form around active...
与锌指结构域 2A 相邻的溴结构域（BAZ2A）基因 | MCE
有助于 RNA 聚合酶 I 核心启动子序列特异性 DNA 结合活性。 预测参与 DNA 甲基化；组蛋白去乙酰化；和大分子代谢过程的负调控。 预计在染色质组织和组蛋白修饰的上游或内部起作用。 位于胞质溶胶和核斑点。 [由基因组资源联盟提供，2022 年 4 月] Enables histone binding activity. Contributes to RNA polymerase I core promoter sequence-specific DNA binding activity.
BAZ2A - Wikipedia
Bromodomain adjacent to zinc finger domain protein 2A is a protein that in humans is encoded by the BAZ2A gene. [5] [6] [7]
An RNA-dependent and phase-separated active subnuclear …
May 2, 2024 · We identified a type of nuclear body with PS features composed of BAZ2A that associates with active chromatin. BAZ2A bodies depend on RNA transcription and BAZ2A non-disordered RNA-binding TAM domain. Although BAZ2A and H3K27me3 occupancies anticorrelate in the linear genome, in the nuclear space, BAZ2A bodies contact H3K27me3 bodies.
BAZ2A bromodomain adjacent to zinc finger domain 2A
Feb 9, 2025 · BAZ2A is overexpressed in prostate cancer, maintains its cell growth, regulates protein-coding genes, and interacts with EZH2 to silence genes repressed in metastasis. Its overexpression is associated with a CpG island methylator phenotype.
BAZ2A (TIP5) is involved in epigenetic alterations in prostate …
BAZ2A regulates numerous protein-coding genes and directly interacts with EZH2 to maintain epigenetic silencing at genes repressed in metastasis. BAZ2A overexpression is tightly associated with a molecular subtype displaying a CpG island methylator phenotype (CIMP).