BACH2 Gene - GeneCards | BACH2 Protein | BACH2 Antibody
Dec 24, 2024 · BACH2 (BTB Domain And CNC Homolog 2) is a Protein Coding gene. Diseases associated with BACH2 include Immunodeficiency 60 And Autoimmunity and …
专家点评 | 伍拓琦/姚辰报道BACH2在维持CD8 T细胞转录和表观组 …
之前报道称bach2有转录抑制的功能，因此研究人员猜测，bach2可能通过抑制终末端分化细胞的基因表达，进而维持了tcf-1hi前体细胞状态。 之后，研究人员在抗原特异性CD8 T细胞内过表达 …
BACH2 - Wikipedia
Transcription regulator protein BACH2 (broad complex-tramtrack-bric a brac and Cap'n'collar homology 2) is a protein that in humans is encoded by the BACH2 gene. [5] [6] [7] It contains a …
BACH2 enforces the transcriptional and epigenetic programs of …
Feb 11, 2021 · Here, we show that the gene encoding transcriptional repressor BACH2 is transcriptionally and epigenetically active in stem-like CD8+ T cells but not terminally …
nature immunology | BACH2调控“调节性”和“促炎性”TH17细胞的 …
Aug 5, 2024 · bach2的作用：验证了bach2在抑制th17细胞致病性、支持类干细胞th17细胞程序以及在自身免疫疾病中的重要作用，揭示了bach2作为潜在治疗靶点的可能性。 治疗潜 …
BACH2 represses effector programs to stabilize T - Nature
Jun 2, 2013 · Here, by studying mice in which the Bach2 gene is disrupted, we define BACH2 as a broad regulator of immune activation that stabilizes immunoregulatory capacity while …
上海市免疫学研究所黄传新团队在Cell Reports发文揭示转录因子Bach2 …
本项研究发现了Bach2能够维持成熟Treg细胞，特别是静息Treg细胞的存活，同时Bach2能够通过直接抑制CD25的表达削弱IL-2R信号通路来抵消这种效应。 这种负向调控能够限制Treg细胞 …
BACH2 regulates diversification of regulatory and …
Jul 15, 2024 · We generated Bach2-knockout (Bach2 KO) T H 17 cells using the CRISPR–Cas9 system, and we confirmed highly efficient insertion/deletion (indel) formation at the target …
科学网—上海交大黄传新课题组揭示转录因子Bach2对Treg和Tfr的 …
May 12, 2021 · 该研究发现，在Treg中，转录因子Bach2能够直接抑制CD25(IL-2Rα)削弱IL-2R信号通路，调控调节性T(Regulatory T, Treg)细胞的稳态和滤泡调节性T(T follicular regulatory, …
BACH2: The Future of Induced T-Regulatory Cell Therapies - MDPI
May 22, 2024 · BACH2 (BTB Domain and CNC Homolog 2) is a transcription factor that serves as a central regulator of immune cell differentiation and function, particularly in T and B …