2024年12月24日 · BACH2 (BTB Domain And CNC Homolog 2) is a Protein Coding gene. Diseases associated with BACH2 include Immunodeficiency 60 And Autoimmunity and Immunodeficiency 60. Among its related pathways are Extrafollicular and follicular B cell activation by SARS-CoV-2 and NF-kappaB Signaling.

之前报道称bach2有转录抑制的功能，因此研究人员猜测，bach2可能通过抑制终末端分化细胞的基因表达，进而维持了tcf-1hi前体细胞状态。 之后，研究人员在抗原特异性CD8 T细胞内过表达了BACH2，发现与对照组相比较，BACH2过表达的细胞显著增高了TCF-1hi细胞的比例和 ...

Transcription regulator protein BACH2 (broad complex-tramtrack-bric a brac and Cap'n'collar homology 2) is a protein that in humans is encoded by the BACH2 gene. [5] [6] [7] It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer [8] and a bZip_Maf domain at the C-terminus.

2021年2月11日 · Here, we show that the gene encoding transcriptional repressor BACH2 is transcriptionally and epigenetically active in stem-like CD8+ T cells but not terminally exhausted cells early after...

2024年8月5日 · bach2的作用：验证了bach2在抑制th17细胞致病性、支持类干细胞th17细胞程序以及在自身免疫疾病中的重要作用，揭示了bach2作为潜在治疗靶点的可能性。 治疗潜力：BACH2在人体CD4+ T细胞中的表达增加与MS等自身免疫疾病的保护性作用相关，提示诱导BACH2表达和/或活性 ...

2013年6月2日 · Here, by studying mice in which the Bach2 gene is disrupted, we define BACH2 as a broad regulator of immune activation that stabilizes immunoregulatory capacity while repressing the ...

本项研究发现了Bach2能够维持成熟Treg细胞，特别是静息Treg细胞的存活，同时Bach2能够通过直接抑制CD25的表达削弱IL-2R信号通路来抵消这种效应。 这种负向调控能够限制Treg细胞在胸腺中的过度产生，并且能够促进CD25-生发中心定位的Tfr细胞分化，调控生发中心反应。

2024年7月15日 · We generated Bach2-knockout (Bach2 KO) T H 17 cells using the CRISPR–Cas9 system, and we confirmed highly efficient insertion/deletion (indel) formation at the target Bach2 locus in T H 17...

2021年5月12日 · 该研究发现，在Treg中，转录因子Bach2能够直接抑制CD25(IL-2Rα)削弱IL-2R信号通路，调控调节性T(Regulatory T, Treg)细胞的稳态和滤泡调节性T(T follicular regulatory, Tfr)细胞的分化。

2024年5月22日 · BACH2 (BTB Domain and CNC Homolog 2) is a transcription factor that serves as a central regulator of immune cell differentiation and function, particularly in T and B lymphocytes. A picture is emerging that BACH2 may function as a master regulator of cell fate that is exquisitely sensitive to cell activation status.