Cell：从氧化应激到癌症——BACH1如何平衡生与死？
机体通过精密的调控机制，在抗氧化与氧化应激之间寻求平衡，其中一个核心参与者便是BACH1——一种兼具转录抑制和癌基因功能的关键因子。 然而，BACH1如何在氧化应激环境 …
BACH1 Gene - GeneCards | BACH1 Protein | BACH1 Antibody
Dec 24, 2024 · BACH1 (BTB Domain And CNC Homolog 1) is a Protein Coding gene. Diseases associated with BACH1 include Beta-Thalassemia and Breast Cancer. Among its related …
Bach1: Function, Regulation, and Involvement in Disease
Oct 2, 2018 · It has a key regulatory role in the production of reactive oxygen species, cell cycle, heme homeostasis, hematopoiesis, and immunity and has been shown to suppress ischemic …
BACH1 - Wikipedia
Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene. [5][6][7] This gene encodes a transcription factor that belongs to the cap'n'collar type of …
转录因子BACH1的研究进展 - shu.edu.cn
BACH1 is a critical factor of stem-cell identity maintenance and mesendodermal differentiation. BACH1 promotes tumor proliferation and metastasis by reprogramming tumor metabolism and …
Bach1蛋白的功能是什么？ - 知乎
根据相关文献报道，Bach1蛋白可以促进糖酵解代谢，促进细胞内葡萄糖的摄取及乳酸的排出；抑制电子传递链（ETC）相关基因的表达。 因此Bach1蛋白可以使得在某些需要大量能量消耗的 …
Nature Communications｜孟丹教授团队揭示BACH1调控肝脏胰岛 …
Dec 25, 2023 · 这项工作表明靶向抑制肝脏BACH1能够明显改善高脂饮食喂养小鼠和db/db糖尿病小鼠的肝脏胰岛素敏感性，改善葡萄糖耐量和糖代谢的异常以及肝脂肪变性。
Nature子刊：复旦大学孟丹团队揭示BACH1调控肝脏胰岛素抵抗新 …
Dec 26, 2023 · 该研究阐明了BACH1在调控肝脏胰岛素敏感性和葡萄糖代谢中的重要作用，为胰岛素抵抗相关疾病的防治提供了新的靶点。 胰岛素抵抗是2型糖尿病的发病基础，也是多种代谢 …
文献精读：巴赫奏鸣曲-解读BACH1在氧化平衡调控中的作用及诱 …
BACH1激活Hk2和Gapdh转录，触发糖酵解诱导肺癌转移。 模式图，圆圈部分对应两个重大发现。 本文思路十分清晰简洁，先重复了下先前的实验结果，然后从小鼠里分离出两种肝癌细胞（对 …
Bach1: Function, Regulation, and Involvement in Disease
Oct 2, 2018 · Bach1 represses the expression of HO-1, which has been shown to upregulate the expression of proangiogenic molecules (e.g., VEGF) and promote neovascularization. Bach1 …