Bromodomain-containing protein 4 is a protein that in humans is encoded by the BRD4 gene. [5] [6] BRD4 is a member of the BET (bromodomain and extra terminal domain) family, which also includes BRD2, BRD3, and BRDT. [7] BRD4, similar to other BET family members, contains two bromodomains that recognize acetylated lysine residues. [8]

Brd4抑制剂通过抑制Brd4与SEs结合，加速SEs与靶向启动子的信号转导，抑制肿瘤细胞癌基因的表达，促进肿瘤细胞死亡 。Brd4抑制剂一般分为两类：单价抑制剂和二价抑制剂。单价抑制剂能与BD1或BD2结合，二价抑制剂能同时与BD1和BD2结合。

Dec 24, 2024 · BRD4 (Bromodomain Containing 4) is a Protein Coding gene. Diseases associated with BRD4 include Cornelia De Lange Syndrome 6 and Cornelia De Lange Syndrome. Among its related pathways are Infectious disease and SARS-CoV-2 Infection. Gene Ontology (GO) annotations related to this gene include chromatin binding and lysine-acetylated histone …

brd4 是一种转录和表观遗传调节因子，在胚胎发生和癌症发展过程中起着关键作用。 作为溴结构域和末端外结构域 (BET) 家族的成员，BRD4 的特征在于具有两个串联溴结构域（BD1、BD2）。

Dec 22, 2023 · Small molecule compound BRD4 BD1 and BD2 bromodomain inhibitors block BRD4 binding to super-enhancers, suppress oncogene transcription and expression, reduce cancer cell proliferation and...

Nov 22, 2018 · BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes expression regulation. Inhibition of BRD4 shortcuts the communication between SEs and target promoters with a subsequent cell-spe …

Nov 22, 2018 · Here we discuss the current available information on non-canonical, non-transcriptional functions of BRD4 and on their implications in cancer biology. Integrating this information with the already known BRD4 role in gene expression regulation, we propose a “common” model to explain BRD4 genomic function.

May 8, 2012 · brd4 蛋白是溴结构域和超末端家族蛋白（bet）家族中最重要的功能蛋白，含两个溴结构域及一个超末端结构域。 brd4 的表达上调与肺癌、乳腺癌、急性髓系淋巴瘤、肝癌等多种肿瘤的发生发展密切相关。

Mar 24, 2021 · BRD4 has emerged as an important factor in tumorigenesis by promoting the transcription of genes involved in cancer development. However, how BRD4 is regulated in cancer cells remains...

bet家族 成员 brd4 是肿瘤发生发展的重要调控因子。在 急性髓系白血病 中，异常激活的brd4定位超乙酰化启动子位点，招募 p-tefb 等中介因子，促进 myc 、 bcl-2 等原癌基因的表达，致使癌症进展。第一代pan bet抑制剂由于剂量依赖毒性，临床推进受限。