2018年11月22日 · BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes expression regulation. Inhibition of BRD4 shortcuts the communication between SEs and target promoters with a subsequent cell-spe …

2024年12月24日 · BRD4 (Bromodomain Containing 4) is a Protein Coding gene. Diseases associated with BRD4 include Cornelia De Lange Syndrome 6 and Cornelia De Lange Syndrome . Among its related pathways are Infectious disease and SARS-CoV-2 Infection .

2023年12月22日 · Small molecule compound BRD4 BD1 and BD2 bromodomain inhibitors block BRD4 binding to super-enhancers, suppress oncogene transcription and expression, reduce cancer cell proliferation and...

2018年11月22日 · BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes expression regulation.

BRD4 is a bromodomain and extra terminal (BET) protein that has been described as a protein with many roles. It has been variously defined as a transcription cofactor, chromatin reader and regulator, recruiting and scaffolding factor, a DNA damage …

2022年10月29日 · Results from the drug screening of 464 inhibitors (for 164 targets) applied to ferroptosis cells indicated that 4 inhibitors targeted bromodomain-containing protein 4 (BRD4) significantly...

These findings provide insight into the role of BRD4 in epigenetic regulation of gene pathways that promote the metastatic phenotype of cancer cells and suggest that therapies targeting BRD4 may represent a strategy to prevent cancer metastasis.

2023年5月1日 · BRD4 facilitates the DNA damage response (DDR) by regulating related genes and BRD4 inhibitors can promote cell death by hindering DDR in cancers, including GBM [41].

BRD4 localizes to the promoter-proximal region of genes. At the target gene BRD4 helps to assemble a functional elongation complex at the 5’-end of genes. During this general 5’-elongation control point BRD4 also recruits 3’-end RNA processing factors.

2021年6月25日 · Bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extraterminal (BET) protein family, plays an important role in controlling oncogene expression and genome stability. In recent years, numerous BRD4 inhibitors have entered clinical trials and achieved exciting results in tumor treatment.